Powder: -20°C for 3 years | In solvent: -80°C for 1 year
ICAM-1-IN-1 是选择性的 ICAM-1和 E-selectin 抑制剂,IC50值分别为5和7 nM。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 1,560 | 现货 | ||
5 mg | ¥ 3,920 | 现货 | ||
10 mg | ¥ 5,590 | 现货 | ||
25 mg | ¥ 8,630 | 现货 | ||
50 mg | ¥ 11,600 | 现货 | ||
100 mg | ¥ 15,600 | 现货 | ||
500 mg | ¥ 31,300 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 4,560 | 现货 |
产品描述 | ICAM-1-IN-1 is a potent and selective E-selectin(IC50 = 7 nM) and ICAM-1(IC50 = 5 nM) inhibitor. |
靶点活性 | Eselectin:7 nM , ICAM1:5 nM |
体内活性 | In a rat rheumatoid arthritis model and in a mouse asthma model,ICAM-1-IN-1 shows significant efficacy . the width of inflamed ankles after the ninth day following treatment reduced by ICAM-1-IN-1, but shows no efficacy in the acute phase. Treatment with ICAM-1-IN-1 (25 mg/kg) for 21 days significantly reduces the ankle inflammation of the arthritis rats. Significant reduction of eosinophils and serum-soluble ICAM-1 (sICAM-1) is observed. |
分子量 | 363.23 |
分子式 | C15H11BrN2O2S |
CAS No. | 251994-14-6 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 135 mg/mL (371.67 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 2.7531 mL | 13.7654 mL | 27.5308 mL | 68.8269 mL |
5 mM | 0.5506 mL | 2.7531 mL | 5.5062 mL | 13.7654 mL | |
10 mM | 0.2753 mL | 1.3765 mL | 2.7531 mL | 6.8827 mL | |
20 mM | 0.1377 mL | 0.6883 mL | 1.3765 mL | 3.4413 mL | |
50 mM | 0.0551 mL | 0.2753 mL | 0.5506 mL | 1.3765 mL | |
100 mM | 0.0275 mL | 0.1377 mL | 0.2753 mL | 0.6883 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
ICAM-1-IN-1 251994-14-6 Cytoskeletal Signaling Integrin ICAM 1 IN 1 inhibit ICAM1IN1 Inhibitor inhibitor