Powder: -20°C for 3 years | In solvent: -80°C for 1 year
IBR2 (Isoquinoline) is a potent and specific RAD51 inhibitor known for its ability to suppress RAD51-mediated DNA double-strand break repair. By interfering with RAD51 multimerization, accelerating proteasome-mediated RAD51 protein degradation, inhibiting cancer cell growth, and inducing apoptosis, IBR2 has proved to be an effective compound in these aspects.
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 398 | 现货 | ||
2 mg | ¥ 572 | 现货 | ||
5 mg | ¥ 879 | 现货 | ||
10 mg | ¥ 1,530 | 现货 | ||
25 mg | ¥ 3,480 | 现货 | ||
50 mg | ¥ 5,130 | 现货 | ||
100 mg | ¥ 7,270 | 现货 | ||
500 mg | ¥ 14,500 | 待询 | ||
1 mL * 10 mM (in DMSO) | ¥ 897 | 现货 |
产品描述 | IBR2 (Isoquinoline) is a potent and specific RAD51 inhibitor known for its ability to suppress RAD51-mediated DNA double-strand break repair. By interfering with RAD51 multimerization, accelerating proteasome-mediated RAD51 protein degradation, inhibiting cancer cell growth, and inducing apoptosis, IBR2 has proved to be an effective compound in these aspects. |
靶点活性 | RAD51:14.8 µM(triple-negative human breast cancer cell line MBA-MD-468) |
体外活性 | IBR2可抑制三阴性人乳腺癌细胞株MBA-MD-468的生长,其半抑制浓度(IC50)为14.8 μM。IBR2展现出对RAD51的显著抑制活性,治疗后的癌细胞中RAD51快速降解,其同源重组修复功能受损,进而导致细胞死亡。IBR2对大多数测试的癌症细胞株的IC50值范围在12-20 μM之间[1]。 |
别名 | Isoquinoline |
分子量 | 400.49 |
分子式 | C24H20N2O2S |
CAS No. | 313526-24-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 100 mg/mL (249.69 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 2.4969 mL | 12.4847 mL | 24.9694 mL | 62.4235 mL |
5 mM | 0.4994 mL | 2.4969 mL | 4.9939 mL | 12.4847 mL | |
10 mM | 0.2497 mL | 1.2485 mL | 2.4969 mL | 6.2424 mL | |
20 mM | 0.1248 mL | 0.6242 mL | 1.2485 mL | 3.1212 mL | |
50 mM | 0.0499 mL | 0.2497 mL | 0.4994 mL | 1.2485 mL | |
100 mM | 0.025 mL | 0.1248 mL | 0.2497 mL | 0.6242 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
IBR2 313526-24-8 Cell Cycle/Checkpoint DNA Damage/DNA Repair DNA/RNA Synthesis RAD51 Apoptosis Isoquinoline IBR 2 inhibit Inhibitor IBR-2 inhibitor