Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Hydroxychloroquine sulfate (Acidum iopanoicum) 抑制疟原虫血红素聚合酶。它还可抑制 Toll 样受体 7/9 信号传导和 SARS-CoV-2 感染。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
50 mg | ¥ 417 | 现货 | ||
100 mg | ¥ 581 | 现货 |
产品描述 | Hydroxychloroquine sulfate (Acidum iopanoicum) inhibits plasmodial heme polymerase. It is a chemotherapeutic agent that acts against erythrocytic forms of malarial parasites. Hydroxychloroquine appears to concentrate in food vacuoles of affected protozoa. |
体外活性 | Hydroxychloroquine sulfate 是一种有效的自噬抑制剂。Hydroxychloroquine sulfate 通过阻止溶酶体酸化从而干扰自噬过程中的关键步骤。HCQ治疗抑制RCC(肾细胞癌)细胞增殖,促进细胞凋亡,抑制线粒体氧气消耗,并提高糖酵解速率[2]。 |
体内活性 | Hydroxychloroquine Sulfate 在大鼠I/R损伤模型中减少梗死面积,其心脏保护作用依赖于ERK1/2[3]。此外,Hydroxychloroquine Sulfate展现出早期的血管保护效应。HCQ似乎能预防接受治疗的动物出现内皮功能障碍(ED)[4]。 |
激酶实验 | In vitro kinase assays: with purified proteins, recombinant S6 protein and recombinant active P70S6K are incubated in 1x kinase buffer with various amount of HCQ or RAD001 in the presence (25 μM) or absence of ATP for 30 minutes at 30°C. Total and phosphorylated S6 at ser235/236 and ser240/244 are detected by western analysis using phosphospecific antibodies. Note that recombinant GST-tagged S6 (53 kd) is distinguished from endogenous S6 (32 kd) on the western blot. |
细胞实验 | All cells are cultured in RPMI with 10% FBS, 1% glutamine, and 1% Pen/Strep. cells are seeded on the appropriated plates overnight and treated with HCQ (75 or 100 μM) for 48 hours.(Only for Reference) |
别名 | Acidum iopanoicum, 硫酸羟基氯喹, 硫酸羟氯喹, HCQ sulfate |
分子量 | 433.95 |
分子式 | C18H26ClN3O·H2SO4 |
CAS No. | 747-36-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: Insoluble
H2O: 10 mM
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
H2O | 1 mM | 2.3044 mL | 11.5221 mL | 23.0441 mL | 57.6103 mL |
5 mM | 0.4609 mL | 2.3044 mL | 4.6088 mL | 11.5221 mL | |
10 mM | 0.2304 mL | 1.1522 mL | 2.3044 mL | 5.761 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Hydroxychloroquine sulfate 747-36-4 Autophagy DNA Damage/DNA Repair Immunology/Inflammation Microbiology/Virology DNA SARS-CoV TLR Parasite Acidum iopanoicum HCQ Inhibitor 硫酸羟基氯喹 Toll-like Receptor (TLR) SARS coronavirus Hydroxychloroquine inhibit Hydroxychloroquine Sulfate 硫酸羟氯喹 HCQ sulfate HCQ Sulfate inhibitor