首页 GPCR/G Protein Histamine Receptor Histamine Phosphate
Histamine Phosphate
编号 T6535     别名: Histamine diphosphate, Histamine acid phosphate, Histamine diphosphate Histamine acid phosphate
CAS 51-74-1     分子式 C5H9N·2H3O4P     分子量 307.14
靶点: H1 receptor; H2 receptor;
Histamine acts directly on the blood vessels to dilate arteries and capillaries mediated by both H 1- and H 2-receptors.
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规格 库存 单价 数量
500 mg 上海现货 393.00
1 g 待询 480.00
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生物活性

产品描述

Histamine acts directly on the blood vessels to dilate arteries and capillaries mediated by both H 1- and H 2-receptors.

靶点活性

H1 receptor,

H2 receptor,

体外活性

Histamine (10 μM) gives a larger inositol monophosphate accumulation in bovine adrenal chromaffin cells. Histamine (10 μM) stimulates the level of radioactivity into the InsP3-containing fraction in bovine adrenal chromaffin cells. Histamine (100 μM) stimulates incorporation into the InsP3-containing eluate in a less extent than for angiotensin I1 and bradykinin. [1]

体内活性

Histamine phosphate (0.025 mg/kg) produces a mean increase in basilar blood flow of 145% of control in dogs. Histamine phosphate produces considerable increases in basilar blood flow as well as a decrease in femoral arterial blood pressure in dogs when injected intravenously and measured with an electromagnetic flow transducer. [2] Histamine phosphate (4 μg/kg) causes lymph flow to increase from 6.0 to 27.0 (SEM) ml/h in unanesthetized sheep. Histamine phosphate (4 μg/kg) also causes increases in lung water, pulmonary vascular resistance, arterial PCO2, pH, and hematocrit, and decreases in cardiac output and arterial PO2 in unanesthetized sheep. [3] Histamine phosphate (8.3 mg/kg/min) causes no significant change in pulmonary lymph flow (QL) or protein concentration (CL) in anesthetized open-chested dogs, however, both are increased after alloxan. Histamine phosphate (8.3 mg/kg/min) also causes no significant change in the pulmonary capillary membrane filtration coefficient (Kf) and the maximum capillary pressure (PCcritical) in anesthetized open-chested dogs. [4] Histamine phosphate (50 mg/kg) produces a pronounced rise in acid secretion but the output of pepsin remained unchanged in the unanaesthetized intact rat. Histamine phosphate (50 mg/kg) produces maximal stimulation of gastric acid secretion and is free from toxic effects in the unanaesthetized intact rat. [5]

化学信息

分子量

307.14

分子式

C5H9N·2H3O4P

CAS

51-74-1

溶解度

H2O: 100 mg/mL (325.58 mM), Need ultrasonic

DMSO: 1.43 mg/mL (4.66 mM), Need ultrasonic

( < 1 mg/ml refers to the product slightly soluble or insoluble )

储存条件

store at -80°C

备注

For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.

配制溶液

1 mg 5 mg 10 mg
1 mM 3.256 ml 16.279 ml 32.558 ml
5 mM 0.651 ml 3.256 ml 6.512 ml
10 mM 0.326 ml 1.628 ml 3.256 ml
50 mM 0.065 ml 0.326 ml 0.651 ml
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