首页 GPCR/G Protein Histamine Receptor Histamine 2HCl
Histamine 2HCl
编号 T6534     别名: peremin, Ceplene, Histamine dihydrochloride, peremin, Histamine dihydrochloride, Ceplene
CAS 56-92-8     分子式 C5H9N3·2HCl     分子量 184.07
靶点: H1 receptor; H2 receptor;
Histamine, an organic nitrogen compound, works on target cells in the mammalian brain by stimulating of Histamine 1/2.
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规格 库存 单价 数量
500 mg 上海现货 395.00
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生物活性

产品描述

Histamine, an organic nitrogen compound, works on target cells in the mammalian brain by stimulating of Histamine 1/2.

靶点活性

H1 receptor,

H2 receptor,

体外活性

Histamine suppresses the generation of ROS through the Histaminetype-2 receptor (H2 receptor).[1] Histamine inhibits the generation and release of reactive oxygen species (ROS) by monocytes/macrophages (MO) during respiratory burst. Histamine and interleukin-2 (IL-2) act synergistically to activate NK cell cytotoxicity (NKCC). Histamine combined with IL-2 might improve response rates and disease-free survival by protecting the cells of the immune system from oxidative stress and inducing natural endogenous immune cytotoxicity. [2]

体内活性

Histamine treatment (0.5 mg/kg or 5.0 mg/kg, twice daily) protects against liver injury as evident by normal serum transaminase levels and significantly reduced liver pathology scores in a rat model with early alcohol-induced liver injury. The protective effect of histamine is blocked by Ranitidine (10 mg/kg), an H2 receptor antagonist, indicating that the histamine effect is predominantly mediated through the H2 receptor. [1] Histamine (30 pg/rat, icv) increases both 3,4-dihydroxyphenylalanine accumulation and 3,4-dihydroxyphenylalanine acid concentrations in the nucleus accumbens in male rats, and this effect is not affect by H2 antagonist zolantidine, indicating that histamine stimulates mesolimbic DA neurons through an action at the H1 receptor. [3] Histamine (0.5 mg/kg s.c.) reduces the liver tumour weight by 46% and subcutaneous tumour weight by 41% versus rats receiving subcutaneous saline injections. The anti-tumour effect observed by subcutaneous histamine injections is inhibited by Ranitidine (50 mg/kg s.c.) in rats sarcoma. [4] Histamine (1000 mg/kg s.c.) displays acute tissue damage after 24 hours and indications of pathological inflammation at the injection sites at 5 days and 28 days in Sprague-Dawley rats. Histamine (1000 mg/kg s.c.) results in Cmax of 167 mM, tmax of 0.5 hour, t1/2 of 0.95 and AUC of 186 mmol-h/L in male Sprague-Dawley rats. [5]

化学信息

分子量

184.07

分子式

C5H9N3·2HCl

CAS

56-92-8

溶解度

DMSO: 18.4 mg/mL (100 mM)

water: 18.4 mg/mL (100 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

储存条件

store at -80°C

备注

For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.

配制溶液

1 mg 5 mg 10 mg
1 mM 5.433 ml 27.164 ml 54.327 ml
5 mM 1.087 ml 5.433 ml 10.865 ml
10 mM 0.543 ml 2.716 ml 5.433 ml
50 mM 0.109 ml 0.543 ml 1.087 ml
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