Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Hirsuteine 是提取自钩藤属植物中的吲哚生物碱。它可阻断离子渗透通过烟碱受体通道复合物,非竞争性地拮抗烟碱介导的多巴胺释放。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 428 | 现货 | ||
5 mg | ¥ 1,060 | 现货 | ||
10 mg | ¥ 1,590 | 现货 | ||
25 mg | ¥ 2,680 | 现货 | ||
50 mg | 特惠询价 | 待询 | ||
1 mL * 10 mM (in DMSO) | ¥ 1,090 | 现货 |
产品描述 | Hirsuteine is a natural product. It non-competitively antagonizes nicotine-mediated dopamine release by blocking ion permeation through nicotinic receptor channel complexes. |
体外活性 | Hirsuteine (300 nM-10 microM) inhibited dopamine release evoked by 100 microM nicotine in a concentration-dependent manner. Hirsuteine did not produce a parallel shift of the concentration-response relationship curve for nicotine, but reduced maximal dopamine release. Dopamine release evoked by 60 and 155 mM KCl was also inhibited by Hirsuteine, but the concentration necessary for significant inhibition was higher (more than 10 microM). Under whole cell voltage-clamp, Hirsuteine reversibly inhibited inward currents activated by 100 microM nicotine. The current inhibition was slightly accelerated by hyperpolarization[1] |
分子量 | 366.45 |
分子式 | C22H26N2O3 |
CAS No. | 35467-43-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 55 mg/mL (150.09 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 2.7289 mL | 13.6444 mL | 27.2889 mL | 68.2221 mL |
5 mM | 0.5458 mL | 2.7289 mL | 5.4578 mL | 13.6444 mL | |
10 mM | 0.2729 mL | 1.3644 mL | 2.7289 mL | 6.8222 mL | |
20 mM | 0.1364 mL | 0.6822 mL | 1.3644 mL | 3.4111 mL | |
50 mM | 0.0546 mL | 0.2729 mL | 0.5458 mL | 1.3644 mL | |
100 mM | 0.0273 mL | 0.1364 mL | 0.2729 mL | 0.6822 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Hirsuteine 35467-43-7 GPCR/G Protein Neuroscience Dopamine Receptor Inhibitor inhibit inhibitor