Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Heparan sulfate 是一种复杂的线性多糖。Heparan sulfate 作为硫酸乙酰肝素蛋白聚糖的一部分出现,在细胞外基质和细胞表面表达丰富。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 393 | 现货 | ||
5 mg | ¥ 913 | 现货 | ||
10 mg | ¥ 1,330 | 现货 | ||
25 mg | ¥ 2,820 | 现货 | ||
50 mg | ¥ 4,250 | 现货 | ||
100 mg | ¥ 5,930 | 现货 |
产品描述 | Heparan Sulfate, a complex and linear polysaccharide, forms a component of glycoproteins called heparan sulfate proteoglycans, abundantly expressed on the cell surface and within the extracellular matrix. |
体外活性 | Heparan sulfate interacts with numerous proteins, including growth factors, morphogens, and adhesion molecules, and thereby regulates important developmental processes in invertebrates and vertebrates. Heparan sulfate chains regulate developmental signaling by acting as co-factors through a variety of mechanisms that include but are not limited to the maintenance of morphogen gradients and co-receptor functions [1]. Heparan sulfate proteoglycans can act as receptors for proteases and protease inhibitors regulating their spatial distribution and activity. Membrane Heparan sulfate proteoglycans act as coreceptors for various tyrosine kinase-type growth factor receptors, lowering their activation threshold or changing the duration of signaling reactions [2]. Heparan sulfate influences the binding affinity of intestinal epithelium cells to Wnt, thereby promoting activation of canonical Wnt signaling and facilitating the regeneration of small intestinal crypts after epithelial injury [3]. |
体内活性 | FGF-2/FGFR system is involved in the regulation of astrocytic reactivity and/or proliferation in the brain and its action is potentiated by heparan sulfate [5]. Digestion of heparan sulfate impairs context discrimination in a fear conditioning paradigm and oscillatory network activity in the low theta band after fear conditioning. Thus, heparan sulfate maintains neuronal excitability and, as a consequence, support synaptic plasticity and learning [4]. |
别名 | 硫酸乙酰肝素, 硫酸类肝素 |
分子量 | 593.47(monomer) |
分子式 | C12H19NO20S3 (monomer) |
CAS No. | 9050-30-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
H2O: 100 mg/mL, Sonication is recommended.
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Heparan Sulfate 9050-30-0 Angiogenesis Cytoskeletal Signaling Metabolism Stem Cells Tyrosine Kinase/Adaptors FGFR Wnt/beta-catenin Endogenous Metabolite Fibroblast growth factor receptor Wnt 硫酸乙酰肝素 硫酸类肝素 Inhibitor Heparan inhibit inhibitor