Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Hemokinin 1 (mouse) acetate(208041-90-1 free base) 是一种选择性兴奋剂 1 受体激动剂,对人 NK1 受体的 Ki 值为 0.175 nM,对人 NK2 受体的 Ki 值为 560 nM。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 1,380 | 现货 | ||
5 mg | ¥ 3,980 | 现货 | ||
10 mg | ¥ 5,690 | 现货 | ||
25 mg | ¥ 8,730 | 现货 | ||
50 mg | ¥ 11,700 | 现货 | ||
100 mg | ¥ 15,800 | 现货 |
产品描述 | Hemokinin 1 (mouse) acetate is a selective excitogen 1 receptor agonist with a Ki value of 0.175 nM for the human NK1 receptor and 560 nM for the human NK2 receptor. |
靶点活性 | NK1:Ki: 0.175 nM (Human), , NK2:ki:560 nM (Human) |
体外活性 | Hemokinin 1 (mouse) (1?nM-3?μM) produces concentration-dependent contraction of RUB averaging 66±3% (n=6) of the maximal contraction produced by KCl (80?mM). Hemokinin 1 (mouse) (10?nM-10?μM) induces a quickly-developing contractile responses of GPI, as does the tachykinin NK3 receptor selective agonist senktide or neurokinin B (NKB). Hemokinin 1 (mouse) induces full agonist responses but with a 500 fold lower potency as compared to NKB[1]. |
体内活性 | Hemokinin 1 (mouse) (0.01-100?nmol/kg i.v., n=10) induces a dose-related hypotension that is maximal at the dose of 10?nmol/kg. For systolic blood pressure (SBP), the ED50 value is 0.2?nmol/kg (0.1-0.4?nmol/kg) for Hemokinin 1 (mouse). For diastolic blood pressure (DBP), the ED50 value is 0.1?nmol/kg (0.07-0.2?nmol/kg) for Hemokinin 1 (mouse). Hemokinin 1 (mouse) (0.1-100?nmol/kg, i.v.) induces a dose-related salivary secretion in atropine-pretreated rats[1]. |
分子量 | 1473.72 |
分子式 | C63H104N22O17S |
CAS No. | TP1772L |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Hemokinin 1 (mouse) acetate(208041-90-1 free base) TP1772L GPCR/G Protein Neuroscience Neurokinin receptor Hemokinin 1 (mouse) acetate(208041901 free base) Hemokinin 1 (mouse) acetate(208041 90 1 free base) Hemokinin 1 acetate(208041-90-1 free base) Inhibitor inhibitor inhibit