Powder: -20°C for 3 years | In solvent: -80°C for 1 year
HSP70-IN-1是一种热休克蛋白 (HSP) 抑制剂,可抑制 Kasumi-1 细胞的生长,IC50值为2.3 μM。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 869 | 现货 | ||
5 mg | ¥ 2,660 | 现货 | ||
10 mg | ¥ 3,990 | 现货 | ||
25 mg | ¥ 6,390 | 现货 | ||
50 mg | ¥ 8,750 | 现货 | ||
100 mg | ¥ 11,700 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 2,660 | 现货 |
产品描述 | HSP70-IN-1 is a heat shock protein (HSP) inhibitor and inhibits the growth of Kasumi-1 cells (IC50: 2.3 μM). |
靶点活性 | HSP:2.3 μM |
体外活性 | The heat shock protein 70 (Hsp70) is a molecular chaperone that plays an important function in protein homeostasis and in cell signaling as well as survival. Hsp70 is frequently overexpressed in cancer, where the elevated expression is further thought to be a cause of or to lead to resistance to chemotherapy and other treatments. HSP70-IN-1 interferes with the formation of functional Hsp70-HOP-Hsp90 machinery by its ability to dose-dependently alter the megacomplex components and to destabilize an Hsp70-Hsp90 machinery client, Raf-1. In cells, the refolding of heat-denatured luciferase by endogenous as well as transfected Hsp70 is inhibited by HSP70-IN-1. HSP70-IN-1 also results in induction of apoptosis in cancer cells. Addition of HSP70-IN-1to cancer cells dose-dependently alters the formation of the Hsp70-HOP complex, a phenomenon associated with their destabilization and reduction in half-life[1]. |
分子量 | 464.58 |
分子式 | C24H28N6O2S |
CAS No. | 1268273-90-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 45 mg/mL (96.86 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 2.1525 mL | 10.7624 mL | 21.5248 mL | 53.812 mL |
5 mM | 0.4305 mL | 2.1525 mL | 4.305 mL | 10.7624 mL | |
10 mM | 0.2152 mL | 1.0762 mL | 2.1525 mL | 5.3812 mL | |
20 mM | 0.1076 mL | 0.5381 mL | 1.0762 mL | 2.6906 mL | |
50 mM | 0.043 mL | 0.2152 mL | 0.4305 mL | 1.0762 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
HSP70-IN-1 1268273-90-0 Cytoskeletal Signaling Metabolism Others HSP HSP70 IN 1 inhibit HSP-70-IN-1 Heat shock proteins Inhibitor HSP70IN1 inhibitor