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HSP27 inhibitor J2

HSP27 inhibitor J2

产品编号 T7265   CAS 2133499-85-9
别名: J2

HSP27 inhibitor J2 (J2) 是一种HSP27抑制剂,可显著增强 17-AAG 的抗增殖活性,并对顺铂诱导的肺癌细胞生长抑制具有敏感性。它显著诱导异常 HSP27 二聚体形成并抑制HSP27巨聚合物的产生,从而具有抑制HSP27的伴侣功能和降低细胞保护功能的作用。

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HSP27 inhibitor J2 Chemical Structure
HSP27 inhibitor J2, CAS 2133499-85-9
规格 价格/CNY 货期 数量
1 mg ¥ 1,230 现货
2 mg ¥ 1,720 现货
5 mg ¥ 2,660 现货
10 mg ¥ 3,990 现货
25 mg ¥ 6,320 现货
50 mg ¥ 8,520 现货
100 mg ¥ 11,500 现货
1 mL * 10 mM (in DMSO) ¥ 3,630 现货
产品目录号及名称: HSP27 inhibitor J2 (T7265)
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生物活性
化学信息
存储 & 溶解度
参考文献
产品描述 HSP27 inhibitor J2 (J2) (J2) is a HSP27 inhibitor, inhibits a production of HSP27 giant polymers, thereby having an effect of inhibiting a chaperone function of the HSP27 and reducing a cell protection function.
体内活性 HSP27 inhibitor (J2) on radiation-induced lung inflammation in comparison to amifostine.In gross and histological findings,J2 treatment significantly inhibited immune cell infiltration in lung tissue, revealing anti-inflammatory potential of J2.Normal lung volume, evaluated by micro-CT analysis, in J2-treated mice was higher compared to that in irradiated mice.J2-treated mice reversed radiation-induced respiratory distress.However, amifostine did not show significant radioprotective effects in comparison to that of J2.In HSP27 transgenic mice, we observed increased immune cells recruitment and decreased volume of normal lung compared to wild type mice.Increased ROS production and oxidative stress after IR were down-regulated by J2 treatment, demonstrating antioxidant property of J2.J2 may be an effective therapeutic agent for radiation-induced lung injury[1].
动物实验 Male C57BL/6 mice (age, 6 weeks; weight, 20–25 g), and were acclimatized (n = 5 per cage) for a week before irradiation. A single dose of 75 Gy was delivered to the left lung in a single fraction using image-guided small-animal irradiator (X-RAD 320) that was equipped with a collimator system composed of 3.5-cm-thick copper to produce focal radiation beams, as well as an imaging subsystem consisting of a fluorescent screen coupled to a charge-coupled-device camera. We selected 3-mm collimators to mimic clinical SBRT conditions by irradiating only a small volume of tissue. The mice were divided into six groups (n = 6–8 per group) as follows: (1) control (C);(2) irradiation (IR) - mice were exposed to a single dose of 75 Gy delivered to the left lung in a single fraction; (3) irradiation + J2 (IR + J2) ?15 mg/kg of J2 was intraperitoneal administered on every other day after irradiation;(4) irradiation + amifostine (IR + Ami) ?100 mg/kg of amifostine were intraperitoneal administered on every other day after irradiation; (5) J2 only (J2) ?15 mg/kg of J2 were intraperitoneal administered on every other day without irradiation; (6) Amifostine only (Ami) ?100 mg/kg of amifostine were intraperitoneal administered on every other day without irradiation. On day 14, mice were sacrificed by CO2 asphyxiation, and their lung tissues were collected for analysis[1].
别名 J2
分子量 264.3
分子式 C13H12O4S
CAS No. 2133499-85-9

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度

DMSO: 22.5 mg/mL (85.13 mM)

溶液配制表

可选溶剂 浓度 体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.7836 mL 18.9179 mL 37.8358 mL 94.5895 mL
5 mM 0.7567 mL 3.7836 mL 7.5672 mL 18.9179 mL
10 mM 0.3784 mL 1.8918 mL 3.7836 mL 9.4589 mL
20 mM 0.1892 mL 0.9459 mL 1.8918 mL 4.7295 mL
50 mM 0.0757 mL 0.3784 mL 0.7567 mL 1.8918 mL

计算器

摩尔浓度计算器
稀释计算器
配液计算器
分子量计算器
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输入分子式,点击计算,可计算出产品的分子量。

参考文献

1. Kim J Y , An Y M , Yoo B R , et al. HSP27 inhibitor attenuates radiation-induced pulmonary inflammation[J]. Scientific Reports, 2018, 8(1):4189. 2. Hwang S Y , Kwak S Y , Kwon Y , et al. Synthesis and biological effect of chrom-4-one derivatives as functional inhibitors of heat shock protein 27[J]. European Journal of Medicinal Chemistry, 2017, 139:892-900.
NCT-58 HSP90-IN-22 Apoptozole JG-231 KRIBB11 Gamitrinib TPP hexafluorophosphate HSP70/SIRT2-IN-2 HSP90-IN-27

相关化合物库

该产品包含在如下化合物库中:
抗癌活性化合物库 抗衰老化合物库 已知活性化合物库 代谢化合物库 NO PAINS 化合物库 抗癌化合物库 抗肺癌化合物库 经典已知活性库 细胞骨架化合物库 抑制剂库

剂量换算

对于不同动物的给药剂量换算,您也可以参考 更多...

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。

母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。

体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。

第一步:请输入动物实验的基本信息
剂量
mg/kg
每只动物体重
g
给药体积
μL
动物数量
第二步:请输入动物体内配方组成,不同的产品配方组成不同,如有配方需求,可先联系我们提供正确的体内配方。
% DMSO
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% Tween 80
% ddH2O
计算 重置

技术支持

您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。

Keywords

HSP27 inhibitor J2 2133499-85-9 Cytoskeletal Signaling Metabolism HSP J2 Heat shock proteins inhibit J-2 HSP-27 inhibitor J2 Inhibitor J 2 inhibitor

 

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