Powder: -20°C for 3 years | In solvent: -80°C for 1 year
H-Tyr(3-I)-OH (3-Iodo-L-tyrosine) 是酪氨酸羟化酶抑制剂和甲状腺激素 的中间体。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
25 mg | ¥ 112 | 现货 | ||
50 mg | ¥ 147 | 现货 | ||
100 mg | ¥ 196 | 现货 | ||
500 mg | ¥ 455 | 现货 | ||
1 g | ¥ 662 | 现货 |
产品描述 | H-Tyr(3-I)-OH (3-Iodo-L-tyrosine) is an inhibitor of tyrosine hydroxylase (Ki = 0.39 M) and an intermediate in the synthesis of thyroid hormones |
体内活性 | 3-iodo-L-tyrosine, at high concentration, is able to induce the intracellular aggregation of αSyn, and death of TH-positive neurons. These phenomena are considered as hallmarks of PD |
动物实验 | Twenty mice were infused with H-Tyr(3-I)-OH into the dorsal striata.?Mice were anesthetized with ketamine (50 mg/kg IP) and xylazine (5mg/kg IP,) and placed in a David Kopf stereotaxic apparatus.?Vehicle and H-Tyr(3-I)-OH solution (0, 1 and 10μM H-Tyr(3-I)-OH dissolved in 0.9% NaCl with 0.001% acetic acid) was slowly injected (5 μl volume) with a blunted 30-gauge cannula at the following coordinates of the left dorsal striata with respect to bregma: AP= +0.86, L= +1.6, and V= -3.5 mm. |
别名 | 3-碘-L-酪氨酸, 3-Iodo-L-tyrosine |
分子量 | 307.09 |
分子式 | C9H10INO3 |
CAS No. | 70-78-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
H2O: 10 mM
DMSO: Insoluble
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
H2O | 1 mM | 3.2564 mL | 16.2819 mL | 32.5637 mL | 81.4094 mL |
5 mM | 0.6513 mL | 3.2564 mL | 6.5127 mL | 16.2819 mL | |
10 mM | 0.3256 mL | 1.6282 mL | 3.2564 mL | 8.1409 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
H-Tyr(3-I)-OH 70-78-0 Metabolism Endogenous Metabolite thyroid hormone inhibit H Tyr(3 I) OH metabolite tyrosine hydroxylase HTyr(3I)OH 3-碘-L-酪氨酸 Inhibitor 3-Iodo-L-tyrosine inhibitor