Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Guanidinosuccinic acid 是一种含氮代谢物,在尿毒症患者的血清和尿液中水平升高。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
10 mg | ¥ 397 | 现货 | ||
25 mg | ¥ 696 | 现货 | ||
50 mg | ¥ 996 | 现货 | ||
100 mg | ¥ 1,497 | 待询 | ||
1 mL * 10 mM (in DMSO) | ¥ 373 | 现货 |
产品描述 | Guanidinosuccinic acid (GSA) has been identified as a uremic toxin, is a nitrogenous metabolite isolated in excess from serum and urine. |
体内活性 | Guanidinosuccinic acid (GSA), a guanidino compound found to be greatly increased in uremia, was administered by intraperitoneal (i.p.) injection to adult albino mice and to young mice 7, 14 and 21 days old.?Epileptogenic and toxic properties were assessed and GSA brain levels following i.p. injection were determined.?In adult mice, GSA induced long-lasting generalized clonic and clonic-tonic convulsions in a dose-dependent manner with a CD50 (and 95% confidence interval) of 363 (287-458) mg/kg (n = 35), and an LD50 of 579 (445-756) mg/kg.?The CD50 of GSA corresponded with a brain concentration of 56 nmol/g tissue.?Electrocorticographic recording in five adult mice revealed epileptiform discharges (spikes, spike-waves, and polyspike-waves) which appeared concomitant with the convulsions.?When young mice were i.p. injected with a (for adults) subconvulsive dose of GSA (250 mg/kg), an age-dependent decrease was noted in GSA-induced convulsions and in the resulting brain concentration[1]. |
别名 | 2-胍基琥珀酸, 胍基琥珀酸 |
分子量 | 175.14 |
分子式 | C5H9N3O4 |
CAS No. | 6133-30-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
H2O: 6 mg/mL (34.26 mM)
DMSO: 75 mg/mL (428.23 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
H2O / DMSO | 1 mM | 5.7097 mL | 28.5486 mL | 57.0972 mL | 142.7429 mL |
5 mM | 1.1419 mL | 5.7097 mL | 11.4194 mL | 28.5486 mL | |
10 mM | 0.571 mL | 2.8549 mL | 5.7097 mL | 14.2743 mL | |
20 mM | 0.2855 mL | 1.4274 mL | 2.8549 mL | 7.1371 mL | |
DMSO | 50 mM | 0.1142 mL | 0.571 mL | 1.1419 mL | 2.8549 mL |
100 mM | 0.0571 mL | 0.2855 mL | 0.571 mL | 1.4274 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Guanidinosuccinic acid 6133-30-8 Metabolism Others Endogenous Metabolite Inhibitor 2-胍基琥珀酸 胍基琥珀酸 inhibit inhibitor