Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Glycopyrrolate (Glycopyrrolate bromide) 是一种毒蕈碱拮抗剂,在某些胃肠道疾病中用作解痉剂,并与某些麻醉剂一起减少唾液分泌。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
5 mg | ¥ 197 | 现货 | ||
10 mg | ¥ 289 | 现货 | ||
25 mg | ¥ 443 | 现货 | ||
50 mg | ¥ 619 | 现货 | ||
100 mg | ¥ 892 | 现货 | ||
500 mg | ¥ 2,270 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 217 | 现货 |
产品描述 | Glycopyrrolate (Glycopyrrolate bromide) is a muscarinic antagonist used as an antispasmodic, in some disorders of the gastrointestinal tract, and to reduce salivation with some anesthetics. |
体外活性 | Glycopyrrolate inhibits EFS-induced contraction of guinea-pig trachea and human airways in a concentration-dependent manner. In competition studies, glycopyrrolate binds human peripheral lung and human airway smooth muscle (HASM) muscarinic receptors with affinities in the nanomolar range (Ki values 0.5–3.6?nM). Glycopyrrolate showed no selectivity in its binding to the M1–M3 receptors. Kinetics studies show that glycopyrrolate dissociates slowly from HASM muscarinic receptors[1]. |
别名 | Gastrodyn, Glycopyrronium bromide, Robinul, Glycopyrrolate bromide, 格隆溴铵 |
分子量 | 398.33 |
分子式 | C19H28BrNO3 |
CAS No. | 596-51-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 60 mg/mL (150.6 mM)
H2O: 72 mg/mL (180.8 mM)
Ethanol: 55 mg/mL (138.1 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO / H2O / Ethanol | 1 mM | 2.5105 mL | 12.5524 mL | 25.1048 mL | 62.762 mL |
5 mM | 0.5021 mL | 2.5105 mL | 5.021 mL | 12.5524 mL | |
10 mM | 0.251 mL | 1.2552 mL | 2.5105 mL | 6.2762 mL | |
20 mM | 0.1255 mL | 0.6276 mL | 1.2552 mL | 3.1381 mL | |
50 mM | 0.0502 mL | 0.251 mL | 0.5021 mL | 1.2552 mL | |
100 mM | 0.0251 mL | 0.1255 mL | 0.251 mL | 0.6276 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Glycopyrrolate 596-51-0 Neuroscience AChR Glycopyrronium Gastrodyn Glycopyrronium bromide Robinul inhibit Glycopyrrolate Bromide Muscarinic acetylcholine receptor mAChR Glycopyrrolate bromide Inhibitor 格隆溴铵 Glycopyrronium Bromide inhibitor