store at low temperture,store under nitrogen | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Glucoraphanin 是一种硫代葡萄糖苷,存在于十字花科蔬菜中,是 Nrf2 诱导剂 sulforaphane 的前体,sulforaphane 有抗氧化、抗炎、抗癌作用。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 361 | 现货 | ||
5 mg | ¥ 913 | 现货 | ||
10 mg | ¥ 1,490 | 现货 | ||
25 mg | ¥ 2,560 | 现货 | ||
50 mg | 特惠询价 | 待询 |
产品描述 | Glucoraphanin, the precursor of the widely extolled chemopreventive agent sulforaphane found in broccoli, has antioxidant activity. |
体内活性 | Glucoraphanin reduces weight gain and increases energy expenditure in HFD-fed mice. Glucoraphanin can improve insulin sensitivity and glucose tolerance in HFD-fed mice. However, Glucoraphanin does not exert antiobesity and insulin-sensitizing effects in Nrf2?/? Mice. Glucoraphanin blocks HFD-induced reduction of Ucp1 protein levels in white adipose depots of wild-type mice but not in Nrf2?/? mice. Glucoraphanin alleviates HFD-induced hepatic steatosis and oxidative stress. Glucoraphanin suppresses HFD-induced proinflammatory activation of macrophages in the liver and adipose tissue [1]. Mice with pellets including 0.1% Glucoraphanin (GF) significantly attenuates the decreased social avoidance time in stressed mice. In the 1% sucrose preference test (SPT), treatment with pellets including 0.1% GF significantly attenuates the decreased sucrose preference of stressed mice [2]. |
动物实验 | Male C57BL/6JSlc mice are 7 weeks of age. The Nrf2 knockout (Nrf2?/?) mouse strain is used in the assay. After 1 week of acclimation, mice are fed normal chow (NC) (containing 2.2% dextrinized cornstarch, 10% kcal from fat), NC containing 0.3% glucoraphanin (NC-GR) (containing 2.2% extract powder), an HFD (containing 2.2% dextrinized cornstarch, 60% kcal from fat), or an HFD containing 0.3% glucoraphanin (HFD-GR) (containing 2.2% extract powder) for 14 weeks. Both the NC and the HFD containing cornstarch or glucoraphanin are prepared. All mice studied are maintained on a 12-h light/dark cycle at 24-26°C with free access to water and food [1]. |
分子量 | 437.51 |
分子式 | C12H23NO10S3 |
CAS No. | 21414-41-5 |
store at low temperture,store under nitrogen | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
H2O: 74 mg/mL(169.14 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
H2O | 1 mM | 2.2857 mL | 11.4283 mL | 22.8566 mL | 57.1416 mL |
5 mM | 0.4571 mL | 2.2857 mL | 4.5713 mL | 11.4283 mL | |
10 mM | 0.2286 mL | 1.1428 mL | 2.2857 mL | 5.7142 mL | |
20 mM | 0.1143 mL | 0.5714 mL | 1.1428 mL | 2.8571 mL | |
50 mM | 0.0457 mL | 0.2286 mL | 0.4571 mL | 1.1428 mL | |
100 mM | 0.0229 mL | 0.1143 mL | 0.2286 mL | 0.5714 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Glucoraphanin 21414-41-5 Immunology/Inflammation Metabolism NF-Κb oxidation-reduction Reactive Oxygen Species Antioxidant Inhibitor inhibit inhibitor