Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Gaultherin 是一种分离自 Gaultheria yunnanensis 中的天然水杨酸酯衍生物。它是一种非甾体类抗炎药,具有止痛和抗炎作用,与 Aspirin 相比没有胃溃疡作用。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 1,080 | 现货 | ||
5 mg | ¥ 2,390 | 现货 | ||
10 mg | ¥ 3,570 | 现货 | ||
25 mg | ¥ 5,860 | 现货 | ||
50 mg | ¥ 8,130 | 现货 | ||
100 mg | ¥ 10,900 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 2,720 | 现货 |
产品描述 | Gaultherin has analgesic, and anti-inflammatory activities.Gaultherin lacks gastric ulcerogenic effect, because of it released salicylate in intestine slowly, not in stomach and it left the cyclooxygenase-1 unaffected, which was the source of cytoprotective prostaglandins in gastric epithelium. |
体外活性 | The synthesis of Gaultherin (1) and its analogs was carried out to provide 11 glycosides under phase-transfer catalytic conditions. METHODS AND RESULTS: The activities of all synthesized compounds were evaluated by nitric oxide production inhibitory assay in vitro. Methyl 2-O-(4-O-β-d-galactopyranosyl)-β-d-glucopyranosylbenzoate (5f) showed significantly anti-nociceptive and anti-inflammatory effects by the evaluation in vivo. Structure-activity relationships within these compounds were discussed. |
分子量 | 446.4 |
分子式 | C19H26O12 |
CAS No. | 490-67-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 50 mg/mL (112.01 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 2.2401 mL | 11.2007 mL | 22.4014 mL | 56.0036 mL |
5 mM | 0.448 mL | 2.2401 mL | 4.4803 mL | 11.2007 mL | |
10 mM | 0.224 mL | 1.1201 mL | 2.2401 mL | 5.6004 mL | |
20 mM | 0.112 mL | 0.56 mL | 1.1201 mL | 2.8002 mL | |
50 mM | 0.0448 mL | 0.224 mL | 0.448 mL | 1.1201 mL | |
100 mM | 0.0224 mL | 0.112 mL | 0.224 mL | 0.56 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Gaultherin 490-67-5 Immunology/Inflammation Neuroscience COX salicylate NSAID Gaultheria yunnanensis Inhibitor analgesic anti-inflammatory inhibit non-steroidal inhibitor