Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Gatifloxacin hydrochloride (AM-1155 hydrochloride) 是一种氟喹诺酮类抗生素,有广谱抗菌活性。它可抑制大肠杆菌 DNA 解旋酶 (IC50=0.109 μg/ml)和细菌 II 型拓扑异构酶(IC50=13.8 μg/ml) 。它在动物模型中,可研究细菌性结膜炎。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
500 mg | ¥ 334 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 208 | 现货 |
产品描述 | Gatifloxacin hydrochloride (AM-1155 hydrochloride) is an antibiotic of the fourth-generation fluoroquinolone family, which can inhibit the bacterial enzyme DNA rotase and topoisomerase IV. |
靶点活性 | Topo II:36.7 μM |
体内活性 | All eyes showed evidence of infection by 48 hours postinoculation with 36 of 41 eyes (87.8%) exhibiting moderate-to-severe keratitis. All eyes exhibited corneal healing by day 15, with no significant differences among groups. Three of 4 groups receiving gatifloxacin tended to have smaller fluorescein retention area scores than did the ciprofloxacin group. No eyes tested positive for Pseudomonas at the end of the study. No corneal precipitates were found following as many as 48 doses/day of gatifloxacin[1]. |
动物实验 | Heptanol-induced corneal ulcers in New Zealand White rabbits (n = 41; 8 females/group) were inoculated with 10(6) CFU of Pseudomonas aeruginosa. Gatifloxacin 0.3% dosing varied among 4 groups with frequencies of 16-48 doses/day (days 1-2), 3-16 doses/day (days 3-7), and maintenance dosing of 3-4 doses/day (days 8-22). Ciprofloxacin 0.3% was administered as labeled for corneal ulcers, with 44 doses on day 1, 16 doses on day 2, and 4 doses/day on days 3-21[1] |
别名 | AM-1155 (hydrochloride), BMS-206584 (hydrochloride), PD135432 (hydrochloride), 加替沙星盐酸盐 |
分子量 | 411.86 |
分子式 | C19H23ClFN3O4 |
CAS No. | 121577-32-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
H2O: 10 mg/mL (24.28 mM), Sonication is recommended.
DMSO: 5 mg/mL (12.14 mM), Sonication is recommended.
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
H2O / DMSO | 1 mM | 2.428 mL | 12.14 mL | 24.2801 mL | 60.7002 mL |
5 mM | 0.4856 mL | 2.428 mL | 4.856 mL | 12.14 mL | |
10 mM | 0.2428 mL | 1.214 mL | 2.428 mL | 6.07 mL | |
H2O | 20 mM | 0.1214 mL | 0.607 mL | 1.214 mL | 3.035 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Gatifloxacin hydrochloride 121577-32-0 DNA Damage/DNA Repair Microbiology/Virology Topoisomerase Antibacterial Antibiotic AM1155 BMS-206584 E. coli,?Pseudomonas aeruginosa,?Micrococcus luteus Gatifloxacin PD-135432 BMS 206584 conjunctivitis N. brasiliensis actinomycetoma AM-1155 (hydrochloride) Inhibitor S. aureus Bacterial BMS-206584 (hydrochloride) inhibit hypoglycemia AM 1155 Gatifloxacin Hydrochloride diabetic PD135432 (hydrochloride) PD135432 hyperglycemia PD 135432 BMS206584 加替沙星盐酸盐 AM-1155 inhibitor