Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Garenoxacin (BMS284756) 是一种新型的口服 des-fluoro(6) 喹诺酮,有抗菌活性,可抑制呼吸道病原体。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
5 mg | ¥ 1,920 | 35日内发货 | ||
10 mg | ¥ 2,880 | 35日内发货 | ||
25 mg | ¥ 6,160 | 35日内发货 |
Garenoxacin 的其他形式现货产品:
产品描述 | Garenoxacin (BMS284756) is a novel oral des-fluoro(6) quinolone for the treatment of Gram-positive and Gram-negative bacterial infections. |
体内活性 | The mean maximum plasma concentration (Cmax ) was 3.00 ± 1.12 μg/mL, time to maximum plasma concentration (Tmax ) was 3.0 ± 2.0 hours, and area under the curve for 24 hours (AUC0-24 ) was 40.7 ± 16.7 μg·h/mL. The half-life (T1/2 ) of GRNX could not be calculated because plasma concentrations remained high 24 hours after administration. Cmax was strongly associated with the GRNX dose per kilogram body weight (r = 0.85, P = 0.03).Clinically, fever resolved within 3 days of GRNX administration and C-reactive protein levels returned to normal 14 days after administration. One patient experienced temporary increases in serum transaminase levels[1]. |
动物实验 | Six male patients with infections who were undergoing MH received 200 mg GRNX once daily. Blood samples were taken before and at 1, 2, 4, 6, 12, and 24 hours after GRNX administration. Plasma GRNX concentrations were measured using high-performance liquid chromatography[1]. |
别名 | BMS284756, 加雷沙星 |
分子量 | 426.41 |
分子式 | C23H20F2N2O4 |
CAS No. | 194804-75-6 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 2 mg/mL (4.69 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 2.3452 mL | 11.7258 mL | 23.4516 mL | 58.629 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Garenoxacin 194804-75-6 Microbiology/Virology Antibacterial S. pneumonia Swiss mice Inhibitor Antibiotic BMS 284756 BMS-284756 BMS284756 DNA/RNA Synthesis Topoisomerase 加雷沙星 S. aureus gyrase mycoplasmas topoisomerase IV ureaplasmas inhibit Bacterial inhibitor