Powder: -20°C for 3 years | In solvent: -80°C for 1 year
GW-6604 是一种 ALK5 抑制剂,具有明显的抗纤维化作用,可改善肝功能。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 517 | 现货 | ||
5 mg | ¥ 1,230 | 现货 | ||
10 mg | ¥ 1,980 | 现货 | ||
25 mg | ¥ 3,570 | 现货 | ||
50 mg | ¥ 5,170 | 现货 | ||
100 mg | ¥ 7,320 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 1,170 | 现货 |
产品描述 | GW-6604 is an ALK5 inhibitor and shows clear antifibrotic effects resulting in liver function improvement. |
体外活性 | GW-6604 inhibited autophosphorylation of ALK5 with an IC50 of 140 nM and in a cellular assay inhibited TGF-beta-induced transcription of PAI-1 (IC50 = 500 nM)[2]. |
体内活性 | GW-6604 (40 mg/kg p.o.) increased liver regeneration in TGF-beta-overexpressing mice, which had undergone partial hepatectomy. In an acute model of liver disease, GW-6604 reduced by 80% the expression of collagen IA1. In a chronic model of DMN-induced fibrosis where DMN was administered for 6 weeks and GW-6604 dosed for the last 3 weeks (80 mg/kg p.o., b.i.d.), mortality was prevented and DMN-induced elevations of mRNA encoding for collagen IA1, IA2, III, TIMP-1 and TGF-beta were reduced by 50-75%. Inhibition of matrix genes overexpression was accompanied by reduced matrix deposition and reduction in liver function deterioration, as assessed by bilirubin and liver enzyme levels[2]. |
分子量 | 298.34 |
分子式 | C19H14N4 |
CAS No. | 452342-37-9 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 2.98 mg/mL (10 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 3.3519 mL | 16.7594 mL | 33.5188 mL | 83.797 mL |
5 mM | 0.6704 mL | 3.3519 mL | 6.7038 mL | 16.7594 mL | |
10 mM | 0.3352 mL | 1.6759 mL | 3.3519 mL | 8.3797 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
GW-6604 452342-37-9 Angiogenesis Metabolism Stem Cells Tyrosine Kinase/Adaptors PAI-1 ALK TGF-beta/Smad GW6604 GW 6604 Inhibitor inhibitor inhibit