首页 Metabolism NADPH GSK2795039
GSK2795039
编号 T15433    
CAS 1415925-18-6     分子式 C23H26N6O2S     分子量 450.56
靶点: Others;
GSK2795039 inhibits reactive oxygen species (ROS) production and NADPH consumption. GSK2795039 decreases apoptosis. GSK2795039 is an inhibitor of NADPH oxidase 2 (NOX2) (pIC50: 6 in different cell-free assays).
选择批次  
规格 库存 单价 数量
1 mg 上海现货 1225.00
5 mg 上海现货 2987.00
10 mg 上海现货 4285.00
35 mg 上海现货 7713.00
1 mL * 10 mM (in DMSO) 上海现货 2985.00
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生物活性

产品描述

GSK2795039 inhibits reactive oxygen species (ROS) production and NADPH consumption. GSK2795039 decreases apoptosis. GSK2795039 is an inhibitor of NADPH oxidase 2 (NOX2) (pIC50: 6 in different cell-free assays).

靶点活性

Others,

体外活性

GSK2795039 (25 μM; 24 hours) decreases the combinatory effect of FeSO4 and LPS-increased levels of apoptosis. It also reduced the presence of caspase-3-positive PC12 cells[2].

体内活性

GSK2795039 (intraperitoneal injection; 100 mg/kg; 1 hour before) reduces activity in a murine model of acute pancreatitis. It also decreases the levels of serum amylase triggered by systemic injection of cerulein[1].

化学信息

分子量

450.56

分子式

C23H26N6O2S

CAS

1415925-18-6

溶解度

DMSO: 31 mg/mL(68.8 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

储存条件

0-4℃ for short term (days to weeks), or -20℃ for long term (months).

备注

For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.

配制溶液

1 mg 5 mg 10 mg
1 mM 2.219 ml 11.097 ml 22.195 ml
5 mM 0.444 ml 2.219 ml 4.439 ml
10 mM 0.222 ml 1.11 ml 2.219 ml
50 mM 0.044 ml 0.222 ml 0.444 ml
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