Powder: -20°C for 3 years | In solvent: -80°C for 1 year
GSK2200150A 是一种通过高通量筛选活动确定的抗结核剂,对 H37Rv 的 MIC 是 0.38 μM。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 243 | 现货 | ||
5 mg | ¥ 563 | 现货 | ||
10 mg | ¥ 886 | 现货 | ||
25 mg | ¥ 1,790 | 现货 | ||
50 mg | ¥ 2,730 | 现货 | ||
100 mg | ¥ 3,990 | 现货 | ||
200 mg | ¥ 5,680 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 618 | 现货 |
产品描述 | GSK2200150A is an anti-tuberculosis (TB) agent identified by high-throughput screening (HTS) campaign. |
靶点活性 | M. tuberculosis (strain H37Rv):0.38 μM (MIC) |
体外活性 | GSK2200150A is a novel antimycobacterial agent against Mycobacterium tuberculosis. The activities of GSK2200150A which contains the spirocycle core are determined against the virulent M.tuberculosis strain (H37Rv) with MIC of 0.38 μM [1]. |
细胞实验 | GSK2200150A is tested for activity at either single concentration (100 μM) or serially diluted in 10 μL of purified H2O in triplicate in 96 well microtiter plates. M. tuberculosis H37Rv is grown in complete Middlebrook 7H9 media containing albumin, dextrose and catalase (ADC), 20% Tween 80 and 50% glycerol. A bacterial suspension (90 μL) at OD600 nm of 0.001 is added to the wells and incubated for 7 days. Resazurin (10 μL; 0.05%(w/v)) is then added, incubated for 24 h at 37°C, and fluorescence measured at 590 nm using a FLUOstar Omega microplate reader. After subtraction of background fluorescence from all wells, the percentage mycobacterial survival is determined by comparing the fluorescence of wells containing compounds compared to control wells not treated with compound[1]. |
分子量 | 357.47 |
分子式 | C20H23NO3S |
CAS No. | 1443138-53-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 80 mg/mL
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
GSK2200150A 1443138-53-1 Microbiology/Virology Antibacterial inhibit Inhibitor GSK-2200150A Bacterial inhibitor