Powder: -20°C for 3 years | In solvent: -80°C for 1 year
GSK-3β inhibitor 2 (5-Thiazolecarboxamide,2-[2-[(cyclopropylcarbonyl)amino]-4-pyridinyl]-4-methoxy-) 是一种特异性的 GSK-3β 抑制剂 (IC50 = 1.1 nM)。 GSK-3β inhibitor 2 可用于阿尔茨海默病的研究。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
5 mg | ¥ 350 | 现货 | ||
10 mg | ¥ 469 | 现货 | ||
25 mg | ¥ 725 | 现货 | ||
50 mg | ¥ 1,370 | 现货 |
产品描述 | GSK-3β inhibitor 2 (5-Thiazolecarboxamide,2-[2-[(cyclopropylcarbonyl)amino]-4-pyridinyl]-4-methoxy-) is a BBB-crossing and selective inhibitor of GSK-3β (IC50 = 1.1 nM). GSK-3β inhibitor 2 can be used in studies about Alzheimer's disease. |
靶点活性 | GSK-3β:1.1 nM |
体外活性 | The pyridine carboxamide of GSK-3β inhibitor 2 makes hydrogen bonds with the hinge V135 backbone amide, and the carbonyl oxygen of the thiazolyl primary amide formed a critical hydrogen bond with K85. The intramolecular hydrogen bonding between the methoxy -O- and the amide N-H in GSK-3β inhibitor 2 is confirmed by single crystal X-ray diffraction method[1]. |
体内活性 | In LaFerla 3xTg-C57BL6 mice with Alzheimer’s disease, GSK-3β inhibitor 2 (30 mg/kg; oral) significantly reduces hyperphosphorylated Tau396. GSK-3β inhibitor 2 shows only modest brain exposure (B/P = 0.26), determined as a single time point[1]. |
别名 | GSK-3β 抑制剂 2, 5-Thiazolecarboxamide,2-[2-[(cyclopropylcarbonyl)amino]-4-pyridinyl]-4-methoxy- |
分子量 | 318.35 |
分子式 | C14H14N4O3S |
CAS No. | 1702428-31-6 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 5 mg/mL (15.71 mM), sonification is recommended.
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 3.1412 mL | 15.706 mL | 31.412 mL | 78.5299 mL |
5 mM | 0.6282 mL | 3.1412 mL | 6.2824 mL | 15.706 mL | |
10 mM | 0.3141 mL | 1.5706 mL | 3.1412 mL | 7.853 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
GSK-3β inhibitor 2 1702428-31-6 PI3K/Akt/mTOR signaling Stem Cells GSK-3 GSK-3β 抑制剂 2 GSK-3b inhibitor 2 5-Thiazolecarboxamide,2-[2-[(cyclopropylcarbonyl)amino]-4-pyridinyl]-4-methoxy- GSK-3beta inhibitor 2 Inhibitor inhibitor inhibit