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GS-441524

产品编号 T7222 CAS 1191237-69-0

别名: GS 441524 triphosphate

GS-441524 是 Remdesivir 的主要活性代谢物，活性更优于 Remdesivir ，治疗患有自然发生的猫传染性腹膜炎的猫。

TargetMol的所有产品和服务仅用于科学研究，不能被用于人体，我们也不向个人提供产品和服务。

GS-441524, CAS 1191237-69-0

规格	价格/CNY		货期	数量
50 mg	￥ 293		现货
1 mL * 10 mM (in DMSO)	￥ 129		现货

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其他形式的 GS-441524:

GS-441524 HCl
询价
GS-443902
询价

选择批次

纯度: 99.9%

纯度: 99.75%

纯度: 99.73%

更多批次查询请联系客服

生物活性

化学信息

存储 & 溶解度

参考文献

相关产品

产品描述	GS-441524 treatment of cats with naturally occurring feline infectious peritonitis.
靶点活性	FIPV:0.78 μM (EC50)
体内活性	Four of the 31 cats that presented with severe disease died or were euthanized within 2-5 days and a fifth cat after 26 days. The 26 remaining cats completed the planned 12 weeks or more of treatment(GS-441524). Eighteen of these 26 cats remain healthy at the time of publication after one round of treatment, while eight others suffered disease relapses within 3-84 days. Six of the relapses were non-neurological and two neurological. Three of the eight relapsing cats were treated again at the same dosage, while five cats had the dosage increased from 2.0 to 4.0 mg/kg q24h. The five cats treated a second time at the higher dosage, including one with neurological disease, responded well and also remain healthy . However, one of the three cats re-treated at the original lower dosage relapsed with neurological disease and was euthanized, while the two remaining cats responded favorably but relapsed a second time. These two cats were successfully treated a third time at the higher dosage, producing 25 long-time survivors. One of the 25 successfully treated cats was subsequently euthanized due to presumably unrelated heart disease, while 24 remain healthy[1].
动物实验	Cats ranged from 3.4-73 months of age (mean 13.6 months); 26 had effusive or dry-to-effusive FIP and five had non-effusive disease. Cats with severe neurological and ocular FIP were not recruited. The group was started on GS-441524 at a dosage of 2.0 mg/kg SC q24h for at least 12 weeks and increased when indicated to 4.0 mg/kg SC q24h[1].

别名	GS 441524 triphosphate
分子量	291.26
分子式	C12H13N5O4
CAS No.	1191237-69-0

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度

DMSO: 50 mg/mL (171.66 mM)

溶液配制表

可选溶剂	浓度体积质量	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	3.4334 mL	17.1668 mL	34.3336 mL	85.834 mL
	5 mM	0.6867 mL	3.4334 mL	6.8667 mL	17.1668 mL
	10 mM	0.3433 mL	1.7167 mL	3.4334 mL	8.5834 mL
	20 mM	0.1717 mL	0.8583 mL	1.7167 mL	4.2917 mL
	50 mM	0.0687 mL	0.3433 mL	0.6867 mL	1.7167 mL
	100 mM	0.0343 mL	0.1717 mL	0.3433 mL	0.8583 mL

计算器

摩尔浓度计算器

稀释计算器

配液计算器

分子量计算器

质量

浓度

容积

分子量

浓度 (起始)

容积 (起始)

浓度 (终)

容积 (终)

溶液体积

质量

配液浓度

参考文献

1. Pedersen N C , Perron M , Bannasch M , et al. Efficacy and safety of the nucleoside analog GS-441524 for treatment of cats with naturally occurring feline infectious peritonitis[J]. Journal of Feline Medicine & Surgery, 2019. 2. Murphy B G , Perron M , Murakami E , et al. The nucleoside analog GS-441524 strongly inhibits feline infectious peritonitis (FIP) virus in tissue culture and experimental cat infection studies[J]. Veterinary Microbiology, 2018, 219:226-233. 3. Xu L, Tan B, Huang D, et al. Remdesivir inhibits renal fibrosis in obstructed kidneys[J]. bioRxiv. 2020. 4. Wang Q, Wu J, Wang H, et al. Structural basis for RNA replication by the SARS-CoV-2 polymerase[J]. Cell. 2020.

文献引用

1. Wang Q, Wu J, Wang H, et al. Structural basis for RNA replication by the SARS-CoV-2 polymerase. Cell. 2020, 182(2): 417-428. e13. 2. Bennett R P, Postnikova E N, Eaton B P, et al. Sangivamycin is highly effective against SARS-CoV-2 in vitro and has favorable drug properties. JCI insight. 2022, 7(1). 3. Xu L, Tan B, Huang D, et al. Remdesivir inhibits renal fibrosis in obstructed kidneys. Frontiers in Pharmacology. 2021, 12: 1668 4. Xu L, Tan B, Huang D, et al. Remdesivir Inhibits Tubulointerstitial Fibrosis in Obstructed Kidneys. Frontiers in Pharmacology. 2021, 12: 1668. 5. Mohseni N, Royster A, Ren S, et al.A novel compound targets the feline infectious peritonitis virus nucleocapsid protein and inhibits viral replication in cell culture.Journal of Biological Chemistry.2023: 102976.

剂量换算

对于不同动物的给药剂量换算，您也可以参考 更多...

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL，一共给药动物10 只，您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。

母液配置方法：2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL)，如您需要配置的浓度超过该产品的溶解度，请先与我们联系。

体内配方的制备方法：取 50 μL DMSO 主液，加入 300 μL PEG300，混匀澄清，再加 50 μL Tween 80，混匀澄清，再加 600 μL ddH2O, 混匀澄清。

第一步：请输入动物实验的基本信息

剂量

mg/kg

每只动物体重

给药体积

μL

动物数量

第二步：请输入动物体内配方组成，不同的产品配方组成不同，如有配方需求，可先联系我们提供正确的体内配方。

% DMSO+

% +

% Tween 80+

% ddH₂O

%DMSO+

计算重置

计算结果如下:

工作液浓度: mg/ml;

母液配置方法: mg 药物溶于 μL DMSO (母液浓度为 mg/mL)，如您需要配置的浓度超过该产品的溶解度，请先与我们联系。

体内配方的制备方法：取 μL DMSO 主液，加入 μL PEG300，混匀澄清，再加 μL Tween 80，混匀澄清，再加 μL ddH₂O, 混匀澄清。

备注:

要按顺序从左向右依次添加助溶剂。可配合物理方法，如涡流、超声波或热水浴使之帮助溶解。

技术支持

您可能有的问题的答案可以在抑制剂处理说明中找到，包括如何准备库存溶液，如何存储产品，以及基于细胞的分析和动物实验需要特别注意的问题。

Keywords

GS-441524 1191237-69-0 Cell Cycle/Checkpoint DNA Damage/DNA Repair Microbiology/Virology Others SARS-CoV DNA/RNA Synthesis Inhibitor feline SARS coronavirus virus GS-441524 Triphosphate GS441524 FIPV infectious peritonitis inhibit GS 441524 Triphosphate GS 441524 triphosphate GS 441524 GS441524 Triphosphate inhibitor

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GS-441524

存储

溶解度

溶液配制表

计算器

输入分子式，点击计算，可计算出产品的分子量。

参考文献

文献引用

相关产品

相关化合物库

剂量换算

体内实验配液计算器

技术支持

Keywords