Powder: -20°C for 3 years | In solvent: -80°C for 1 year
GENZ-882706 is a potent colony stimulating factor-1 receptor (CSF-1R) Inhibitor.
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
25 mg | ¥ 16,200 | 10-14周 | ||
50 mg | ¥ 21,100 | 10-14周 | ||
100 mg | ¥ 31,400 | 10-14周 |
产品描述 | GENZ-882706 is a potent colony stimulating factor-1 receptor (CSF-1R) Inhibitor. |
体外活性 | Genz-882706 induces an increased level of proliferative activity on unstimulated cells 48 hours post treatmen. |
体内活性 | Daily treatment with Genz-882706 significantly reduces experimental autoimmune encephalomyelitis. Treatment with Genz-882706 in experimental autoimmune encephalomyelitis (EAE) mice results in significant decreases in MCP-1, IL-6, IL-Ιβ and IP-10 levels in spinal cord homogenates when compared to Vehicle treated animals. Treatment with Genz-882706 shows a significant increase in TNF-a levels in the spinal cord when compared to the vehicle treated group. Genz-882706 at both the 30 mg/kg and the 100 mg/kg dose significantly reduces the number of microglia and monocytes/macrophages in the brain and spinal cord compared to the vehicle and LPS controls. Treatment with Genz-882706 modestly reduces CD80 expression on monocytes/macrophages in the brain. |
别名 | RA03546849 |
分子量 | 455.51 |
分子式 | C26H25N5O3 |
CAS No. | 2070864-35-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
GENZ-882706 2070864-35-4 Tyrosine Kinase/Adaptors CSF-1R RA 03546849 GENZ 882706 RA-03546849 RA03546849 GENZ882706 Inhibitor inhibitor inhibit