Powder: -20°C for 3 years | In solvent: -80°C for 1 year
GC7 Sulfate 是 deoxyhypusine synthase(DHS)有效抑制剂。真核翻译起始因子5A2 (eIF5A2)是DHS 已知的底物,因此GC7通过抑制DHS 活性来抑制eIF5A2的激活。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 446 | 现货 | ||
5 mg | ¥ 947 | 现货 | ||
10 mg | ¥ 1,590 | 现货 | ||
25 mg | ¥ 3,180 | 现货 | ||
50 mg | ¥ 4,720 | 现货 | ||
100 mg | ¥ 6,720 | 现货 | ||
500 mg | ¥ 13,500 | 现货 |
产品描述 | GC7 Sulfate is a potent inhibitor of deoxyhypusine synthase (DHS). Eukaryotic translation initiation factor 5A2 (eIF5A2) is the only known substrate for DHS, so GC7 inhibits the activation of eIF5A2 by inhibiting DHS activity. |
靶点活性 | Spermidine:10 nM(ki) |
体外活性 | Cell cycle analysis show that GC7 Sulfate reduces the CHO-K1 cell population in the G1-phase of the cell cycle by 42% and increases the number of cells in the S-phase by 44%. Furthermore, GC7 Sulfate inhibited the growth of H9 cells in a concentration-dependent manner. While 1 μM GC7 Sulfate had no significant effect on H9 cell proliferation, inhibition of growth became evident with 3 μM GC7 Sulfate. At 10 μM GC7 Sulfate, H9 cell growth was completely blocked within 1 or 2 days after the addition of the drug[1]. |
分子量 | 270.35 |
分子式 | C8H22N4O4S |
CAS No. | 150417-90-6 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
H2O: 2.7 mg/mL (10.0 mM), sonification/heating is recommended.
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
H2O | 1 mM | 3.6989 mL | 18.4945 mL | 36.9891 mL | 92.4727 mL |
5 mM | 0.7398 mL | 3.6989 mL | 7.3978 mL | 18.4945 mL | |
10 mM | 0.3699 mL | 1.8495 mL | 3.6989 mL | 9.2473 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
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