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GALNON TFA(475115-35-6(free base))

GALNON TFA(475115-35-6(free base))

产品编号 T8559   CAS T8559

GALNON TFA(475115-35-6(free base)) 是一种新型非肽甘丙肽受体激动剂(GAL1 和 GAL2,Ki 分别为 11.7 和 34.1 μM)。

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GALNON TFA(475115-35-6(free base)) Chemical Structure
GALNON TFA(475115-35-6(free base)), CAS T8559
规格 价格/CNY 货期 数量
1 mg ¥ 1,290 现货
2 mg ¥ 1,930 现货
5 mg ¥ 2,920 现货
10 mg ¥ 4,320 现货
25 mg ¥ 6,890 现货
50 mg ¥ 9,330 现货
100 mg ¥ 12,500 现货
500 mg ¥ 25,200 现货
1 mL * 10 mM (in DMSO) ¥ 1,750 现货
其他形式的 GALNON TFA(475115-35-6(free base)):
产品目录号及名称: GALNON TFA(475115-35-6(free base)) (T8559)
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生物活性
化学信息
存储 & 溶解度
参考文献
产品描述 Galnon is a novel non-peptide galanin receptor agonist (GAL1 and GAL2 with Ki of 11.7 and 34.1 μM respectively).
体内活性 Galnon stimulated insulin release potently in isolated Wistar rat islets; 100 microM of the compound increased the release 8.5 times (p<0.001) at 3.3 mM and 3.7 times (p<0.001) at 16.7 mM glucose. Also in islet perifusions, galnon augmented several-fold both acute and late phases of insulin response to glucose. Furthermore, galnon stimulated insulin release in GK rat islets. These effects were not inhibited by the presence of galanin or the galanin receptor antagonist M35. The stimulatory effects of galnon were partly inhibited by the PKA and PKC inhibitors, H-89 and calphostin C, respectively, at 16.7 but not 3.3 mM glucose. In both Wistar and GK rat islets, insulin release was stimulated by depolarization of 30 mM KCl, and 100 microM galnon further enhanced insulin release 1.5-2 times (p<0.05). Cytosolic calcium levels, determined by fura-2, were increased in parallel with insulin release, and the L-type Ca2+-channel blocker nimodipine suppressed insulin response to glucose and galnon[1].galnon, a GAL receptor agonist, may enhance osteoclastic bone resorption in OVX rats. Although galnon reduced bone volume, biomechanical testing revealed that bone of galnon-treated animals was mechanically superior per unit area. Taken together, galnon simultaneously improves the intrinsic quality of cortical bone whilst stimulating osteoclastic activity in the OVX rat model[2].
动物实验 OVX rats were treated with either vehicle or galnon for 6 weeks via mini-osmotic pumps. Plasma osteocalcin concentrations, osseous cell gene expression, morphological and biomechanical properties of the skeleton were compared between the two groups[2]
分子量 92.84
分子式 C42H47F3N4O8
CAS No. T8559

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度

DMSO: 25 mg/mL (269.28 mM)

溶液配制表

可选溶剂 浓度 体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 10.7712 mL 53.8561 mL 107.7122 mL 269.2805 mL
5 mM 2.1542 mL 10.7712 mL 21.5424 mL 53.8561 mL
10 mM 1.0771 mL 5.3856 mL 10.7712 mL 26.928 mL
20 mM 0.5386 mL 2.6928 mL 5.3856 mL 13.464 mL
50 mM 0.2154 mL 1.0771 mL 2.1542 mL 5.3856 mL
100 mM 0.1077 mL 0.5386 mL 1.0771 mL 2.6928 mL

计算器

摩尔浓度计算器
稀释计算器
配液计算器
分子量计算器
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参考文献

1. Quynh N T T , Islam S M , Anders Florén, et al. Effects of galnon, a non-peptide galanin-receptor agonist, on insulin release from rat pancreatic islets[J]. Biochem Biophys Res Commun, 2005, 328(1):213-220. 2. Mcgowan H W , Schuijers J A , Grills B L , et al. Galnon, a galanin receptor agonist, improves intrinsic cortical bone tissue properties but exacerbates bone loss in an ovariectomised rat model[J]. Journal of musculoskeletal & neuronal interactions, 2014, 14(2):162-172.
Pancreatic Polypeptide (human) acetate Neuropeptide SF(mouse,rat) acetate RFRP-1 (human) acetate(311309-25-8 free base) BMS-193885 Spexin acetate(1370290-58-6 free base) HT-2157 Neuropeptide S (Rat) acetate WAY-639889

相关化合物库

该产品包含在如下化合物库中:
神经信号分子库 已知活性化合物库 经典已知活性库 神经递质受体化合物库 GPCR靶点分子库 NO PAINS 化合物库

剂量换算

对于不同动物的给药剂量换算,您也可以参考 更多...

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。

母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。

体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。

第一步:请输入动物实验的基本信息
剂量
mg/kg
每只动物体重
g
给药体积
μL
动物数量
第二步:请输入动物体内配方组成,不同的产品配方组成不同,如有配方需求,可先联系我们提供正确的体内配方。
% DMSO
%
% Tween 80
% ddH2O
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技术支持

您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。

Keywords

GALNON TFA(475115-35-6(free base)) T8559 GPCR/G Protein Neuroscience Neuropeptide Y Receptor GALNON TFA(475115356(free base)) GALNON TFA(475115 35 6(free base)) Inhibitor inhibitor inhibit

 

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