Powder: -20°C for 3 years | In solvent: -80°C for 1 year
G-1 是一种高亲和力的、非甾体的、有选择性的 GPR30激动剂(Ki:11 nM)。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 455 | 现货 | ||
5 mg | ¥ 778 | 现货 | ||
10 mg | ¥ 1,230 | 现货 | ||
25 mg | ¥ 2,260 | 现货 | ||
50 mg | ¥ 3,730 | 现货 | ||
100 mg | ¥ 5,390 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 690 | 现货 |
产品描述 | G-1 is a nonsteroidal, high-affinity and selective GPR30 agonist (Ki: 11 nM). |
靶点活性 | GPR30:(ki)11 nM |
体外活性 | Treatment with G-1 (10 μM and 100 μM; 48 and 72 h) obviously reduces cell proliferation (P<0.001). At 72 h, the IC50 value for G-1 is calculated to be 20 μM. Cell cycle analysis of H295R cells after 24 h of G-1 treatment shows a cell cycle arrest in the G2 phase. Treatment of A549 cells with G-1(20 μM) reveals a significant increase in apoptosis, consistent with its antiproliferative effect (P<0.001)[2]. The presence of G-1 increases Bax expression while reduces Bcl-2[3]. |
体内活性 | After 14 days post-injury, the results display that the Basso mouse scale scores are obviously higher in the G-1 group compared with the other groups (P<0.05). G-1 administration produces a statistically significant induce in tumor volume from day 14 post-treatment. Grafted tumors harvested after a three-week treatment with G-1 show a significant decrease in tumor weight compare to vehicle-treated animals[3]. The number of caspase-3-positive cells in the cross-sections is counted, and G-1 group has fewer positive cells compared with the other groups (P<0.05), and there is no difference between the two groups (P>0.05)[1]. |
分子量 | 412.28 |
分子式 | C21H18BrNO3 |
CAS No. | 881639-98-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
H2O: < 0.1 mg/mL (insoluble)
DMSO: 50 mg/mL (121.28 mM), Sonication is recommended.
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 2.4255 mL | 12.1277 mL | 24.2554 mL | 60.6384 mL |
5 mM | 0.4851 mL | 2.4255 mL | 4.8511 mL | 12.1277 mL | |
10 mM | 0.2426 mL | 1.2128 mL | 2.4255 mL | 6.0638 mL | |
20 mM | 0.1213 mL | 0.6064 mL | 1.2128 mL | 3.0319 mL | |
50 mM | 0.0485 mL | 0.2426 mL | 0.4851 mL | 1.2128 mL | |
100 mM | 0.0243 mL | 0.1213 mL | 0.2426 mL | 0.6064 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
G-1 881639-98-1 Endocrinology/Hormones GPCR/G Protein Estrogen Receptor/ERR GPR Inhibitor inhibit G1 G 1 inhibitor