Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Fmoc-Val-Ala-PAB-OH (Fmoc-Val-Ala-PAB) 是一种有用的接头,可用于制备用于靶向药物递送的抗体-药物偶联物。它还用于合成带有溶酶体可切割接头的 RGD 拟肽-紫杉醇缀合物。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
25 mg | ¥ 345 | 现货 | ||
50 mg | ¥ 485 | 现货 | ||
100 mg | ¥ 731 | 现货 |
产品描述 | Fmoc-Val-Ala-PAB-OH (Fmoc-Val-Ala-PAB) is a useful linker for making Antibody-Drug-Conjugation (ADC) conjugate for targeting drug delivery. It is also utilized in the synthesis of RGD peptidomimetic-paclitaxel conjugates bearing lysosomally cleavable linkers. |
体内活性 | Osilodrostat and pasireotide monotherapies can significantly affect in the histology and mean weights of the pituitary and adrenal glands, liver, and ovary/oviduct. Osilodrostat is associated with adrenocortical hypertrophy and hepatocellular hypertrophy. The combination of Osilodrostat with pasireotide ameliorates the liver and adrenal gland changes observed with monotherapy and does not exacerbate any target organ changes. Cmax and AUC(0–24h) of Osilodrostat and pasireotide increase in an approximately dose-proportional manner. Osilodrostat treatment reduces urinary free cortisol in patients with Cushing's disease; 78.9% has normal urinary free cortisol at week 22. |
别名 | Fmoc-Val-Ala-PAB |
分子量 | 515.6 |
分子式 | C30H33N3O5 |
CAS No. | 1394238-91-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 10 mM
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 1.9395 mL | 9.6974 mL | 19.3949 mL | 48.4872 mL |
5 mM | 0.3879 mL | 1.9395 mL | 3.879 mL | 9.6974 mL | |
10 mM | 0.1939 mL | 0.9697 mL | 1.9395 mL | 4.8487 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Fmoc-Val-Ala-PAB-OH 1394238-91-5 Neuroscience Others AChR Fmoc-Val-Ala-PAB Inhibitor Antibody-drug conjugates linkers ADC Linkers Fmoc Val Ala PAB OH inhibit FmocValAlaPABOH inhibitor