Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Flumexadol is a selective and affinity 5-HT2C receptor agonist with a Ki of 25 nM for the (+)-enantiomer of Flumexadol, and is 40-fold selective over the 5-HT2A receptor. Flumexadol is an orally active non-narcotic analgesic.
产品描述 | Flumexadol is a selective and affinity 5-HT2C receptor agonist with a Ki of 25 nM for the (+)-enantiomer of Flumexadol, and is 40-fold selective over the 5-HT2A receptor. Flumexadol is an orally active non-narcotic analgesic. |
靶点活性 | 5-HT2C receptor:25 nM (ki) |
体内活性 | In rats and dogs dosed with 14C-Flumexadol (CERM1841), the 14C is excreted in the urine.?The 14C eliminated in the faeces of dog is significantly higher than for rat.?Conjugated metabolites, mostly glucuronides, accounted for the greater part of the urinary radioactivity in both species.?Biotransformation products are predominantly acids in both species, follows by significant amounts of basic metabolites, with very little neutral substances.?The major urinary metabolite in rats is 3-trifluoromethylbenzoic acid and 3-trifluoromethylhipuric acid.?In the dog it is 3-trifluoromethylmandelic acid in addition to the benzoic acid and its conjugate.?The basic products identified in the urine of both species are unchanged drug and 1-amino-2-hydroxy-2-(3-trifluoromethylphenyl)ethane, with the first predominating. |
分子量 | 231.21 |
分子式 | C11H12F3NO |
CAS No. | 30914-89-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 100 mg/mL (432.51 mM), Sonication is recommended.
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 4.3251 mL | 21.6254 mL | 43.2507 mL | 108.1268 mL |
5 mM | 0.865 mL | 4.3251 mL | 8.6501 mL | 21.6254 mL | |
10 mM | 0.4325 mL | 2.1625 mL | 4.3251 mL | 10.8127 mL | |
20 mM | 0.2163 mL | 1.0813 mL | 2.1625 mL | 5.4063 mL | |
50 mM | 0.0865 mL | 0.4325 mL | 0.865 mL | 2.1625 mL | |
100 mM | 0.0433 mL | 0.2163 mL | 0.4325 mL | 1.0813 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Flumexadol 30914-89-7 GPCR/G Protein Neuroscience 5-HT Receptor Inhibitor inhibitor inhibit