Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Floxuridine (FUDR) 是一种嘧啶类似物,也是一种抗肿瘤代谢物。它抑制胸苷酸合成酶,导致 DNA 合成中断和细胞毒性。它是一种可诱导细胞凋亡的金黄色葡萄球菌感染抑制剂 ,具有抗HSV 和CMV 病毒的作用。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
10 mg | ¥ 242 | 现货 | ||
25 mg | ¥ 387 | 现货 | ||
50 mg | ¥ 559 | 现货 | ||
100 mg | ¥ 822 | 现货 | ||
200 mg | ¥ 1,230 | 现货 | ||
500 mg | ¥ 2,490 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 255 | 现货 |
产品描述 | Floxuridine (FUDR) is an antimetabolite, floxuridine inhibits thymidylate synthase, resulting in disruption of DNA synthesis and cytotoxicity. |
体外活性 | Floxuridine exhibits higher affinity for PEPT1 than the corresponding 5'-O-mono amino acid ester prodrugs. [1] Floxuridine combined with Leucovorin results in synergistic inhibitory effects on growth of human T-lymphoblast leukemia cells. [2] Floxuridine significantly inhibits the uptake of both [(3)H]-inosine and [(3)H]-adenosine (60-70% of control), while its amino acid ester prodrugs including Val, Phe, Pro, Asp, and Lys esters exhibits markedly decreased inhibition potency (10-30% of control). [3] Floxuridine inhibits cell proliferation by more than 50% relative to the untreated control cells at 36 days, the cell numbers still increases fourfold compared with the initial cell density. Floxuridine results in prolonged effects on the proliferation of human Tenon's capsule fibroblasts in vitro. [4] Floxuridine (FUDR) is an ideal drug for hepatic arterial infusion (HAI) due to its short half life, steep dose response curve, high total body clearance, and high hepatic extraction. [5] |
别名 | 氟尿苷, 5-Fluorouracil 2'-deoxyriboside, FUDR, Deoxyfluorouridine, NSC 27640 |
分子量 | 246.19 |
分子式 | C9H11FN2O5 |
CAS No. | 50-91-9 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
H2O: 24.6 mg/mL (100 mM)
DMSO: 24.6 mg/mL (100 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
H2O / DMSO | 1 mM | 4.0619 mL | 20.3095 mL | 40.619 mL | 101.5476 mL |
5 mM | 0.8124 mL | 4.0619 mL | 8.1238 mL | 20.3095 mL | |
10 mM | 0.4062 mL | 2.031 mL | 4.0619 mL | 10.1548 mL | |
20 mM | 0.2031 mL | 1.0155 mL | 2.031 mL | 5.0774 mL | |
50 mM | 0.0812 mL | 0.4062 mL | 0.8124 mL | 2.031 mL | |
100 mM | 0.0406 mL | 0.2031 mL | 0.4062 mL | 1.0155 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Floxuridine 50-91-9 Apoptosis Cell Cycle/Checkpoint DNA Damage/DNA Repair Microbiology/Virology Others Nucleoside Antimetabolite/Analog DNA/RNA Synthesis Antibacterial HSV S. aureus cancer Ovarian Antimetabolite Herpes simplex virus 氟尿苷 CMV Inhibitor Oncology Cytomegalovirus 5-Fluorouracil 2'-deoxyriboside OVCAR-8 NSC27640 Bacterial SKOV3ip FUDR NSC-27640 Deoxyfluorouridine inhibit cells polymerase NSC 27640 inhibitor