Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Flesinoxan is a hypotensive agent and is an effective, high affinity, and selective 5-hydroxytryptamine1A receptor agonist (EC50: 24 nM).
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
2 mg | ¥ 3,190 | 5日内发货 | ||
5 mg | ¥ 3,730 | 5日内发货 | ||
25 mg | ¥ 12,100 | 8-10周 | ||
50 mg | ¥ 15,800 | 8-10周 | ||
100 mg | ¥ 23,500 | 8-10周 | ||
1 mL * 10 mM (in DMSO) | ¥ 4,120 | 5日内发货 |
产品描述 | Flesinoxan is a hypotensive agent and is an effective, high affinity, and selective 5-hydroxytryptamine1A receptor agonist (EC50: 24 nM). |
靶点活性 | 5-HT1A receptor:24 nM (EC50) |
体内活性 | Flesinoxan acts as a partial agonist at postsynaptic and as a full agonist at presynaptic 5-HT1A receptors. The intravenous administration of Flesinoxan suppresses the firing activity of both CA3 pyramidal neurons and dorsal raphe 5-HT neurons. The capacity of Flesinoxan to antagonize the effect of 5-HT on CA3 pyramidal neurons was similar to that of 8-OH-DPAT. The acute brain penetration of [3H]Flesinoxan and [3H]8-OH-DPAT are determined. Nine minutes after intravenous administration, [3H]8-OH-DPAT reached significantly greater brain concentration than [3H]Flesinoxan. Subcutaneous administration of Flesinoxan and 8-OH-DPAT produce dose-dependent hypothermia. The Flesinoxan-induced hypothermia is significantly attenuated by prior administration of the non-selective 5-HT1A antagonist pindolol and the 5-HT1/2 antagonist methysergide. Similar degrees of hypothermia is achieved with 3 mg/kg of Flesinoxan and 0.5 mg/kg of 8-OH-DPAT. The maximal effect of Flesinoxan occurs 30 min later than that of 8-OH-DPAT and fades more slowly. |
分子量 | 415.46 |
分子式 | C22H26FN3O4 |
CAS No. | 98206-10-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 31.25 mg/mL (75.22 mM), Sonication is recommended.
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 2.407 mL | 12.0349 mL | 24.0697 mL | 60.1743 mL |
5 mM | 0.4814 mL | 2.407 mL | 4.8139 mL | 12.0349 mL | |
10 mM | 0.2407 mL | 1.2035 mL | 2.407 mL | 6.0174 mL | |
20 mM | 0.1203 mL | 0.6017 mL | 1.2035 mL | 3.0087 mL | |
50 mM | 0.0481 mL | 0.2407 mL | 0.4814 mL | 1.2035 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Flesinoxan 98206-10-1 GPCR/G Protein Neuroscience 5-HT Receptor Inhibitor inhibitor inhibit