Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Fingolimod (FTY-720A) 是一种 1-磷酸鞘氨醇 (S1P) 拮抗剂,作用于 K562 和 NK 细胞,IC50为 0.033 nM。它还是pak1激活剂和免疫抑制剂。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
100 mg | ¥ 457 | 现货 | ||
500 mg | ¥ 1,255 | 现货 | ||
1 g | ¥ 1,570 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 544 | 现货 |
产品描述 | Fingolimod (FTY-720A) is an antagonist of sphingosine 1-phosphate (S1P) (IC50 of 0.033 nM in K562 and NK cells). |
靶点活性 | sphingosine 1-phosphate (S1P):0.033 nM |
体外活性 | Fingolimod has been reported to reduce LPA synthesis via inhibition of the lysophospholipase autotaxin.?Fingolimod treatment correlates with a significant elevation of axonal cAMP, a crucial factor for axonal outgrowth.?Additionally, Fingolimod significantly reduces LPA levels in the injured nerve.?PF-8380 treatment correlates with improved myelin thickness[1] |
细胞实验 | Sciatic nerve crush was performed in wildtype C57BL/6, in immunodeficient Rag1 (-/-) and Foxn1 (-/-) mice.?Analyses were based on walking track analysis and electrophysiology, histology, and cAMP formation.?Quantification of different LPA species was performed by liquid chromatography coupled to tandem mass spectrometry.?Furthermore, functional consequences of autotaxin inhibition by the specific inhibitor PF-8380 and the impact of fingolimod on early cytokine release in the injured sciatic nerve were investigated[1]. |
别名 | 2-氨基-2-[2-(4-辛基苯基)乙基]-1,3-丙二醇, FTY-720A, FTY-720, 芬戈莫德 |
分子量 | 307.47 |
分子式 | C19H33NO2 |
CAS No. | 162359-55-9 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Methanol: 30 mg/mL (97.57 mM), sonification is recommended.
Ethanol: 7.69 mg/mL (25.01 mM), sonification is recommended.
DMSO: 66.67 mg/mL (216.83 mM), sonification is recommended.
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
Methanol / Ethanol / DMSO | 1 mM | 3.2523 mL | 16.2617 mL | 32.5235 mL | 81.3087 mL |
5 mM | 0.6505 mL | 3.2523 mL | 6.5047 mL | 16.2617 mL | |
10 mM | 0.3252 mL | 1.6262 mL | 3.2523 mL | 8.1309 mL | |
20 mM | 0.1626 mL | 0.8131 mL | 1.6262 mL | 4.0654 mL | |
Methanol / DMSO | 50 mM | 0.065 mL | 0.3252 mL | 0.6505 mL | 1.6262 mL |
DMSO | 100 mM | 0.0325 mL | 0.1626 mL | 0.3252 mL | 0.8131 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Fingolimod 162359-55-9 Cytoskeletal Signaling GPCR/G Protein S1P Receptor PAK LPL Receptor Inhibitor inhibit 2-氨基-2-[2-(4-辛基苯基)乙基]-1,3-丙二醇 FTY720 FTY 720 FTY-720A Lysophospholipid Receptor FTY-720 p21 activated kinases 芬戈莫德 inhibitor