Fenoprofen calcium hydrate

产品编号: T6498 别名:

Fenoprofen calcium salt dihydrate,Progesic dihydrate,非诺洛芬钙二水合物,Feprona dihydrate

Fenoprofen calcium hydrate是一非甾体类抗炎症化合物。

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Fenoprofen calcium hydrate Chemical Structure

CAS：71720-56-4

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生物活性化学信息储存和溶解度信息参考文献引用文献

产品描述

Fenoprofen calcium hydrate is a non-steroidal anti-inflammatory drug (NSAID).

体外活性

Fenoprofen is a more potent inhibitor of collagen-induced platelet aggregation than either aspirin or phenylbutazone. [1] Fenoprofen inhibits the formation of palmitoyl-CoA in both microsomal and peroxisomal fractions, and inhibits the beta-oxidation of lignoceric acid and cerotic acid in rat hepatocytes. [5] Fenoprofen exhibits modest antiproliferative activity against HT-29, DID-1, and SW480 cells with IC50 of 240 μM, 300 μM, and 360 μM, respectively. [6] Fenoprofen (0.1 mM) is an efficient activator of peroxisome proliferator-activated receptor gamma (PPARγ), activating the receptor to a degree comparable to that obtained with the PPARγ ligands BRL49653 and 15-deoxy-D12,14-PGJ2 and the peroxisome proliferator Wy14643. Fenoprofen is also an efficacious activator of PPARα, activating the receptor to a degree comparable to that obtained with the strong peroxisome proliferator Wy14643. Consistently, Fenoprofen treatment promotes lipogenesis in C3H10T1/2 cells. [7] Although Fenoprofen displays only modest antiproliferative activity, Fenoprofen amides can potently induce cell cycle arrest at the G1 phase, as well as apoptosis, probably because of a greater lipophilicity and/or better cell uptake. [9]

体内活性

Oral administration of Fenoprofen at 50 mg/kg potently inhibits thrombus formation by 47%, whereas a dose of 200 mg/kg of aspirin is required to reduce thrombus formation 21 %. [1] Similar to indomethacin, adminstration of Fenoprofen inhibits prostaglandin synthesis. [2] In rats with type II collagen-induced arthritis, Fenoprofen treatment at 40 mg/kg/day partially suppresses the paw swelling, but has no significant effect on humoral and cellular responses. [3] Administration of Fenoprofen depresses the rebound contraction, thus transforming the brisk relaxant response, elicited by vagal stimulation or ATP, into long-lasting relaxation. [4] Administration of Fenoprofen causes a strong and dose-related induction of peroxisomal palmitoyl-CoA oxidase, and of carnitine acyltransferase and acyl-CoA hydrolase activities in liver homogenates of mice fed diets. Hepatic catalase activity is significantly increased in mice fed the diet with 0.05 and 0.1% fenoprofen but not the 1% fenoprofen-containing diet. [8]

细胞实验

Cells are exposed to various concentrations of Fenoprofen for 6 days. Cell number is determined using the SRB colonimetnic protein stain assay. After 6 days of culture, cells are fixed by the addition of cold trichloroacetic acid to a final concentration of 10%. Plates are incubated at 4 °C for 1 hour, then the supernatant is aspirated and the plates are washed with deionized water. SRB solution is formulated to 0.4% w/v in 1% acetic acid; 100 μL is added to each well and the plates are incubated for 10 minutes at room temperature. Unbound SRB is removed by washing with 1% acetic acid followed by air drying. Bound stain is solubilized with 50 mM unbuffered Tris and absorbance is read by an automated spectrophotometer at a single wavelength of 540 nm.(Only for Reference)

Cas No.

71720-56-4

分子式

C15H14O3·1/2Ca·H2O

分子量

558.63

别名

Fenoprofen calcium salt dihydrate;Progesic dihydrate;非诺洛芬钙二水合物;Feprona dihydrate;Fenoprofen calcium hydrate

参考文献

[1]Lageweg W, et al. Biochem Pharmacol, 1993, 46(1), 79-85.[2]Patrono C, et al. Pharmacol Res Commun, 1974, 6(5), 509-518.[3]Herrmann RG, et al. Proc Soc Exp Biol Med, 1972, 139(2), 548-552.[4]Baccari MC, et al. Exp Physiol, 1990, 75(3), 415-418.[5]Phadke K, et al. Clin Exp Immunol, 1982, 47(3), 579-586.

储存和溶解度

Ethanol:15 mg/mL (19.1 mM)
DMSO:45 mg/mL (57.3 mM)
H2O:<1 mg/mL
Powder: -20°C for 3 years
In solvent: -80°C for 2 years

剂量换算 Fenoprofen calcium hydrate 71720-56-4

对于各种应用，安全且有效的用药剂量是很有必要的了解更多

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剂量 mg/kg

每只动物体重 g

给药体积 ul

动物数量

第二步：请输入动物体内配方组成，不同的产品配方组成不同，如有配方需求，可先联系我们提供正确的体内配方。

% DMSO +

% +

% Tween 80 +

% ddH₂O

% DMSO +

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计算结果如下:

工作液浓度: mg/ml;

母液配置方法: mg 药物溶于 μL DMSO (母液浓度为 mg/mL)，如您需要配置的浓度超过该产品的溶解度，请先与我们联系。

体内配方的制备方法：取 μL DMSO 主液，加入 μL PEG300，混匀澄清，再加 μL Tween 80，混匀澄清，再加 μL ddH₂O, 混匀澄清。

备注:

要按顺序从左向右依次添加助溶剂。可配合物理方法，如涡流、超声波或热水浴使之帮助溶解。

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技术支持

在抑制剂处理说明中可以找到您可能遇到的问题的答案。主题包括如何准备储备溶液，如何存储产品以及基于细胞的测定和动物实验需要特别注意的问题。

Keywords

Apoptosis Cyclooxygenase Fenoprofen calcium salt dihydrate inhibit Fenoprofen Calcium Fenoprofen calcium hydrate Progesic dihydrate Inhibitor COX 非诺洛芬钙二水合物 Feprona dihydrate 71720-56-4

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Fenoprofen calcium hydrate

Fenoprofen calcium salt dihydrate,Progesic dihydrate,非诺洛芬钙二水合物,Feprona dihydrate

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