Favipiravir

产品编号: T6833 别名:

T-705,6-Fluoro-3-oxo-3,4-dihydropyrazine-2-carboxamide,法匹拉韦,法维拉韦

Favipiravir 是一种有效且选择性的 RNA 依赖性 RNA 聚合酶抑制剂，用于治疗流感病毒感染。

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CAS：259793-96-9

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生物活性化学信息储存和溶解度信息参考文献引用文献

产品描述

Favipiravir (T-705), an effective and selective RNA-dependent RNA polymerase inhibitor, are applied to treat influenza virus infections.

体外活性

Favipiravir shows anti-influenza virus activities with IC50 ranged from 0.013 to 0.48 μg/ml for the influenza A viruses, from 0.039 to 0.089 μg/ml for the influenza B viruses, and from 0.030 to 0.057 μg/ml for the influenza C viruses. In mammalian cell lines (MDCK cells, Vero cells, HEL cells, A549 cells, HeLa cells, and HEp-2 cells), Favipiravir shows no cytotoxicity at concentrations up to 1,000 μg/ml. [1] In MDCK cells inoculated with seasonal influenza A (H1N1) viruses, Favipiravir induces lethal mutagenesis. [2]

体内活性

In influenza virus-infected mice, Favipiravir (200 mg/kg/day, p.o.) protects the mice from death from influenza virus infection. [1] In mice experimentally infected with Ebola virus, Favipiravir efficiently blocks viral production, reaching an antiviral effectiveness of 95% and 99.6% at 2 and 6days after initiation of treatment, respectively. [3]

细胞实验

The cytotoxicity of T-705 is evaluated by an assay with XTT. XTT is converted to aqueous formazan by an enzyme in MDCK cells, Vero cells, HEL cells, A549 cells, HeLa cells, and HEp-2 cells. The compounds are diluted to the appropriate concentrations (volume, 100 μl) with test medium (EMEM containing 10% FCS) in 96-well culture plates in which each well contains a concentration of 2 × 103 cells/100 μL. The test plates are incubated for 3 days at 37°C in 100% humidity and 5% CO2. After 3 days, 50 μl of the XTT reagent (1 mg/ml in FCS-free EMEM containing 5 mM phenazine methosulfate) is added, and the reaction product is assayed by measurement of the absorbance at 450 nm with a microplate reader. Cytotoxicity is expressed as the 50% cell-inhibitory concentration (CC50).(Only for Reference)

Cas No.

259793-96-9

分子式

C5H4FN3O2

分子量

157.104

别名

T-705;6-Fluoro-3-oxo-3,4-dihydropyrazine-2-carboxamide;法匹拉韦;法维拉韦;Favipiravir

参考文献

[1]Furuta Y, et al. Antimicrob Agents Chemother. 2002, 46(4), 977-981.[2]Qiu M, Li Z, Chen Y, et al. Tolcapone Potently Inhibits Seminal Amyloid Fibrils Formation and Blocks Entry of Ebola Pseudoviruses. Frontiers in Microbiology. 2020, 11: 504.[3]WEI X U, Shuai X, Jing P, et al. The antihistamine drugs carbinoxamine maleate and chlorpheniramine maleate exhibit potent antiviral activity against a broad spectrum of influenza viruses[J]. Frontiers in Microbiology. 2018 Nov 6;9:2643.[4]Madelain V, et al. Antiviral Res. 2015, 123, 70-77.[5]Baranovich T, et al. J Virol. 2013, 87(7), 3741-3751.

引用文献

[1]Nicholson M W, Huang C Y, Wang J Y, et al. Cardio-and Neurotoxicity of Selected Anti-COVID-19 Drugs. Pharmaceuticals. 2022, 15(6): 765 [2]Qiu M, Li Z, Chen Y, et al. Tolcapone Potently Inhibits Seminal Amyloid Fibrils Formation and Blocks Entry of Ebola Pseudoviruses. Frontiers in Microbiology. 2020, 11: 504 [3]WEI X U, Shuai X, Jing P, et al. The antihistamine drugs carbinoxamine maleate and chlorpheniramine maleate exhibit potent antiviral activity against a broad spectrum of influenza viruses. Frontiers in Microbiology. 2018 Nov 6;9:2643

储存和溶解度

Ethanol:12 mg/mL(76.4 mM)
H2O:5 mg/mL (31.82 mM)
DMSO:29 mg/mL (184.6 mM)

Powder: -20°C for 3 years
In solvent: -80°C for 2 years

剂量换算 Favipiravir 259793-96-9

对于各种应用，安全且有效的用药剂量是很有必要的了解更多

体内实验配液计算器

第一步：请输入动物实验的基本信息

剂量 mg/kg

每只动物体重 g

给药体积 ul

动物数量

第二步：请输入动物体内配方组成，不同的产品配方组成不同，如有配方需求，可先联系我们提供正确的体内配方。

% DMSO +

% +

% Tween 80 +

% ddH₂O

% DMSO +

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计算结果如下:

工作液浓度: mg/ml;

母液配置方法: mg 药物溶于 μL DMSO (母液浓度为 mg/mL)，如您需要配置的浓度超过该产品的溶解度，请先与我们联系。

体内配方的制备方法：取 μL DMSO 主液，加入 μL PEG300，混匀澄清，再加 μL Tween 80，混匀澄清，再加 μL ddH₂O, 混匀澄清。

备注:

要按顺序从左向右依次添加助溶剂。可配合物理方法，如涡流、超声波或热水浴使之帮助溶解。

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技术支持

在抑制剂处理说明中可以找到您可能遇到的问题的答案。主题包括如何准备储备溶液，如何存储产品以及基于细胞的测定和动物实验需要特别注意的问题。

Keywords

SARS-CoV T-705 DNA/RNA Synthesis Influenza Virus T705 inhibit SARS coronavirus Favipiravir Inhibitor 6-Fluoro-3-oxo-3,4-dihydropyrazine-2-carboxamide T 705 法匹拉韦法维拉韦 259793-96-9

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Favipiravir

T-705,6-Fluoro-3-oxo-3,4-dihydropyrazine-2-carboxamide,法匹拉韦,法维拉韦

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