Powder: -20°C for 3 years | In solvent: -80°C for 1 year
FPS-ZM1 是一种高亲和力的 RAGE 特异性抑制剂,可阻断 Aβ 与 RAGE 的 V 结构域的结合。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 185 | 现货 | ||
5 mg | ¥ 413 | 现货 | ||
10 mg | ¥ 622 | 现货 | ||
25 mg | ¥ 1,120 | 现货 | ||
50 mg | ¥ 1,970 | 现货 | ||
100 mg | ¥ 2,970 | 现货 | ||
200 mg | ¥ 4,390 | 现货 | ||
500 mg | ¥ 6,900 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 455 | 现货 |
产品描述 | FPS-ZM1 is a high-affinity RAGE specific inhibitor that blocks Aβ binding to the V domain of RAGE. |
靶点活性 | RAGE:25 nM. (Ki) |
体外活性 | FPS-ZM1 blocks Aβ binding to the V domain of RAGE and inhibited Aβ40- and Aβ42-induced cellular stress in RAGE-expressing cells in vitro. It blocks binding of other ligands to RAGE as well, such as S100B, AGE, and HMGB1, which have been suggested to contribute to RAGE-mediated long-term tissue damage in models of diabetes, immune/inflammatory disorders, and AD[1]. |
体内活性 | FPS-ZM1 is nontoxic to mice and readily crossed the blood-brain barrier (BBB).It effectively controls progression of an Aβ-mediated brain disorder and the related neurovascular and cognitive dysfunction in 17-month-old APPsw/0 mice with fully developed Aβ and amyloid pathology by blocking RAGE actions at the BBB and in brain. Also, FPS-ZM1 blocks RAGE-dependent BACE1 expression and activity in brain of 17-month-old APPsw/0 mice[1]. |
激酶实验 | Human sRAGE is immobilized (10 μg/mL) overnight at 4°C in 96-well microtiter plates and blocked with 3% bovine serum albumin. 125I-labeled Aβ40, HMGB1, or S100B at 5 nM in the absence and presence of various concentrations of FPS2 or FPS-ZM1 (10 to 1,000 nM) is added to the wells containing immobilized sRAGE and incubated for 1 hour at room temperature in PBS. Wells are washed with cold PBS to remove unbound radiolabeled ligands, and the radioactivity is analyzed[1]. |
细胞实验 | CHO cells are treated for 72 hours with different concentrations of inhibitors ranging from 10 nM to 10 μM. The cellular toxicity was determined using the WST-8 Assay Kit. (Only for Reference) |
分子量 | 327.85 |
分子式 | C20H22ClNO |
CAS No. | 945714-67-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 198.3 mM
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 3.0502 mL | 15.2509 mL | 30.5018 mL | 76.2544 mL |
5 mM | 0.61 mL | 3.0502 mL | 6.1004 mL | 15.2509 mL | |
10 mM | 0.305 mL | 1.5251 mL | 3.0502 mL | 7.6254 mL | |
20 mM | 0.1525 mL | 0.7625 mL | 1.5251 mL | 3.8127 mL | |
50 mM | 0.061 mL | 0.305 mL | 0.61 mL | 1.5251 mL | |
100 mM | 0.0305 mL | 0.1525 mL | 0.305 mL | 0.7625 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
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