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FPS-ZM1

FPS-ZM1

产品编号 T3259   CAS 945714-67-0

FPS-ZM1 是一种高亲和力的 RAGE 特异性抑制剂,可阻断 Aβ 与 RAGE 的 V 结构域的结合。

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FPS-ZM1 Chemical Structure
FPS-ZM1, CAS 945714-67-0
规格 价格/CNY 货期 数量
1 mg ¥ 185 现货
5 mg ¥ 413 现货
10 mg ¥ 622 现货
25 mg ¥ 1,120 现货
50 mg ¥ 1,970 现货
100 mg ¥ 2,970 现货
200 mg ¥ 4,390 现货
500 mg ¥ 6,900 现货
1 mL * 10 mM (in DMSO) ¥ 455 现货
产品目录号及名称: FPS-ZM1 (T3259)
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纯度: 99.3%
纯度: 98.39%
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生物活性
化学信息
存储 & 溶解度
参考文献
产品描述 FPS-ZM1 is a high-affinity RAGE specific inhibitor that blocks Aβ binding to the V domain of RAGE.
靶点活性 RAGE:25 nM. (Ki)
体外活性 FPS-ZM1 blocks Aβ binding to the V domain of RAGE and inhibited Aβ40- and Aβ42-induced cellular stress in RAGE-expressing cells in vitro. It blocks binding of other ligands to RAGE as well, such as S100B, AGE, and HMGB1, which have been suggested to contribute to RAGE-mediated long-term tissue damage in models of diabetes, immune/inflammatory disorders, and AD[1].
体内活性 FPS-ZM1 is nontoxic to mice and readily crossed the blood-brain barrier (BBB).It effectively controls progression of an Aβ-mediated brain disorder and the related neurovascular and cognitive dysfunction in 17-month-old APPsw/0 mice with fully developed Aβ and amyloid pathology by blocking RAGE actions at the BBB and in brain. Also, FPS-ZM1 blocks RAGE-dependent BACE1 expression and activity in brain of 17-month-old APPsw/0 mice[1].
激酶实验 Human sRAGE is immobilized (10 μg/mL) overnight at 4°C in 96-well microtiter plates and blocked with 3% bovine serum albumin. 125I-labeled Aβ40, HMGB1, or S100B at 5 nM in the absence and presence of various concentrations of FPS2 or FPS-ZM1 (10 to 1,000 nM) is added to the wells containing immobilized sRAGE and incubated for 1 hour at room temperature in PBS. Wells are washed with cold PBS to remove unbound radiolabeled ligands, and the radioactivity is analyzed[1].
细胞实验 CHO cells are treated for 72 hours with different concentrations of inhibitors ranging from 10 nM to 10 μM. The cellular toxicity was determined using the WST-8 Assay Kit. (Only for Reference)
分子量 327.85
分子式 C20H22ClNO
CAS No. 945714-67-0

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度

DMSO: 198.3 mM

溶液配制表

可选溶剂 浓度 体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.0502 mL 15.2509 mL 30.5018 mL 76.2544 mL
5 mM 0.61 mL 3.0502 mL 6.1004 mL 15.2509 mL
10 mM 0.305 mL 1.5251 mL 3.0502 mL 7.6254 mL
20 mM 0.1525 mL 0.7625 mL 1.5251 mL 3.8127 mL
50 mM 0.061 mL 0.305 mL 0.61 mL 1.5251 mL
100 mM 0.0305 mL 0.1525 mL 0.305 mL 0.7625 mL

计算器

摩尔浓度计算器
稀释计算器
配液计算器
分子量计算器
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输入分子式,点击计算,可计算出产品的分子量。

参考文献

1. Deane R, et al. J Clin Invest. 2012, 122(4):1377-1392. 2. He C, Sun S, Zhang Y, et al. The role of irreversible electroporation in promoting M1 macrophage polarization via regulating the HMGB1-RAGE-MAPK axis in pancreatic cancer[J]. OncoImmunology. 2021, 10(1): 1897295.

文献引用

1. He C, Sun S, Zhang Y, et al. The role of irreversible electroporation in promoting M1 macrophage polarization via regulating the HMGB1-RAGE-MAPK axis in pancreatic cancer. OncoImmunology. 2021 Mar 11;10(1):1897295. doi: 10.1080/2162402X.2021.1897295.
(+)-Medioresinol 20(S)-Ginsenoside Rg3 Azeliragon Deferoxamine Mesylate MAO-B-IN-9 MDR-1339 Putraflavone Frentizole

相关化合物库

该产品包含在如下化合物库中:
神经退行性疾病化合物库 神经信号分子库 抑制剂库 已知活性化合物库 经典已知活性库 血脑屏障通透化合物库 NO PAINS 化合物库 表型筛选靶点鉴定库 干细胞分化化合物库 抗阿尔茨海默症化合物库

剂量换算

对于不同动物的给药剂量换算,您也可以参考 更多...

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。

母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。

体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。

第一步:请输入动物实验的基本信息
剂量
mg/kg
每只动物体重
g
给药体积
μL
动物数量
第二步:请输入动物体内配方组成,不同的产品配方组成不同,如有配方需求,可先联系我们提供正确的体内配方。
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% ddH2O
计算 重置

技术支持

您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。

Keywords

FPS-ZM1 945714-67-0 Neuroscience Others Beta Amyloid advanced glycation end products β-amyloid peptide Amyloid-β Inhibitor inhibit FPS-ZM-1 FPS ZM1 FPSZM1 Abeta inhibitor

 

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