Powder: -20°C for 3 years | In solvent: -80°C for 1 year
FK706 is a slow-binding and competitive human neutrophil elastase inhibitor (IC50: 83 nM; Ki: 4.2 nM). FK706 also inhibits mouse neutrophil elastase and porcine pancreatic elastase (IC50s: 22 nM and 100 nM, respectively). FK706 has an anti-inflammatory effect.
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
2 mg | ¥ 2,630 | 5日内发货 | ||
25 mg | ¥ 14,700 | 8-10周 | ||
50 mg | ¥ 19,200 | 8-10周 | ||
100 mg | ¥ 25,500 | 8-10周 |
产品描述 | FK706 is a slow-binding and competitive human neutrophil elastase inhibitor (IC50: 83 nM; Ki: 4.2 nM). FK706 also inhibits mouse neutrophil elastase and porcine pancreatic elastase (IC50s: 22 nM and 100 nM, respectively). FK706 has an anti-inflammatory effect. |
靶点活性 | Neutrophil elastase (human):(ki)4.2 nM, Neutrophil elastase (human):83 nM, Neutrophil elastase (mouse):22 nM, Pancreatic elastase (porcine):100 nM |
体外活性 | FK706 effectively inhibits the hydrolysis of bovine neck ligament elastin (2 mg/mL final concentration) by human neutrophil elastase (4 μg/mL final concentration) (IC50: 230 nM) [1]. FK706 blocks the release of inflammatory chemokines, suppresses the expression of IL-8 and MCP-1 mRNA, and suppresses NF-κB activation. FK706 may directly block human lung fibroblasts activation of NF-κB, preventing the expression of inflammatory chemokines during cigarette smoke-induced lung inflammation [2]. |
体内活性 | FK706 (10-100 mg/kg; subcutaneous injection; for 1-6 hours; male C57BL mice) treatment obviously inhibits human neutrophil elastase (20 μg/paw)-induced paw edema in mice. It shows a dose-dependent manner (47% inhibition at a dose of 100 mg/kg) [1]. |
分子量 | 593.556 |
分子式 | C26H33F3N4NaO7 |
CAS No. | 144055-55-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
FK706 144055-55-0 Proteases/Proteasome Serine Protease FK 706 FK-706 Inhibitor inhibitor inhibit