Powder: -20°C for 3 years | In solvent: -80°C for 1 year
FIDAS-3 是一种强效Wnt 抑制剂,也是一种二苯乙烯衍生物,对甲硫氨酸腺苷转移酶 2A (MAT2A) 的IC50为 4.9 μM。它能够与 S-腺苷甲硫氨酸有效竞争MAT2A 结合,并具有抗癌作用。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 463 | 现货 | ||
5 mg | ¥ 1,080 | 现货 | ||
10 mg | ¥ 1,690 | 现货 | ||
25 mg | ¥ 2,880 | 现货 | ||
50 mg | ¥ 4,190 | 现货 | ||
100 mg | ¥ 5,980 | 现货 | ||
500 mg | ¥ 11,900 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 948 | 现货 |
产品描述 | FIDAS-3 effectively competes against S-adenosylmethionine (SAM) for MAT2A binding. FIDAS-3 has anticancer activities. FIDAS-3 is a stilbene derivative and is a potent Wnt inhibitor with an IC50 of 4.9 μM for methionine S-adenosyltransferase 2A (MAT2A). |
靶点活性 | Mat2A:4.9 μM |
体外活性 | FIDAS-3 induces the expression of cell cycle inhibitor, p21WAF1/CIP1.?FIDAS-3 (10 μM;?36 h) treatment reduces the levels of both S-adenosylmethionine (SAM) and S-adenosylhomocysteine (SAH) in LS174T cells.FIDAS-3 (3 μM; 7 days; LS174T cells) treatment significantly inhibits the proliferation of LS174T cells. FIDAS-3 (3-10 μM) treatment inhibits the expression of c-Myc and cyclinD1 in LS174T CRC cells. |
体内活性 | FIDAS-3 (20 mg/kg;?intraperitoneal injection;?daily;?for one months;?C57BL/6J athymic nude mice) treatment significantly inhibits the growth of xenograft tumors. |
分子量 | 259.29 |
分子式 | C16H15F2N |
CAS No. | 1266684-01-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 90mg/ml(347.10mM), sonification is recommended.
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 3.8567 mL | 19.2834 mL | 38.5669 mL | 96.4171 mL |
5 mM | 0.7713 mL | 3.8567 mL | 7.7134 mL | 19.2834 mL | |
10 mM | 0.3857 mL | 1.9283 mL | 3.8567 mL | 9.6417 mL | |
20 mM | 0.1928 mL | 0.9642 mL | 1.9283 mL | 4.8209 mL | |
50 mM | 0.0771 mL | 0.3857 mL | 0.7713 mL | 1.9283 mL | |
100 mM | 0.0386 mL | 0.1928 mL | 0.3857 mL | 0.9642 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
FIDAS-3 1266684-01-8 Chromatin/Epigenetic Cytoskeletal Signaling Others Stem Cells Wnt/beta-catenin Methionine Adenosyltransferase (MAT) Inhibitor Wnt CyclinD1 anti-proliferation FIDAS3 c-Myc MAT2A FIDAS 3 β-catenin S-adenosylmethionine anti-cancer SAH inhibit SAM inhibitor