Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Etravirine (R165335) 是一种非核苷逆转录酶抑制剂,具有抗 HIV 的作用。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
2 mg | ¥ 295 | 现货 | ||
5 mg | ¥ 478 | 现货 | ||
10 mg | ¥ 797 | 现货 | ||
25 mg | ¥ 1,460 | 现货 | ||
50 mg | ¥ 2,260 | 现货 | ||
100 mg | ¥ 3,380 | 现货 | ||
200 mg | ¥ 4,820 | 现货 | ||
1 g | ¥ 6,590 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 659 | 现货 |
产品描述 | Etravirine (R165335) is a diarylpyrimidine non-nucleoside reverse transcriptase inhibitor. Etravirine is designed to be active against HIV isolates with mutations that confer resistance to the two most commonly prescribed first-generation NNRTIs. It can bind the enzyme reverse transcriptase (RT) in multiple conformations, both for native and mutant RT, thereby blocking the enzymatic activity of RT. |
体外活性 | Etravirine (TMC125), is highly active against wild-type HIV-1 with EC50 of 1.4 nM to 4.8 nM and shows some activity against HIV-2 with EC50 of 3.5 μM. TMC125 also inhibits a series of HIV-1 group M subtypes and circulating recombinant forms and a group O virus. [1] [2] |
体内活性 | Etravirine has a high genetic barrier to the development of resistance. TMC125 is active against HIV resistant to currently available NNRTIs, with a similar tolerability profile to that of the control group in phase IIb trials in treatment-experienced patients, including those infected with virus resistant to NNRTIs and protease inhibitors (PIs)[3]. |
别名 | TMC125, 依曲韦林, R165335 |
分子量 | 435.28 |
分子式 | C20H15BrN6O |
CAS No. | 269055-15-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Ethanol: < 1 mg/mL (insoluble or slightly soluble)
DMSO: 39 mg/mL (89.6 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 2.2974 mL | 11.4869 mL | 22.9737 mL | 57.4343 mL |
5 mM | 0.4595 mL | 2.2974 mL | 4.5947 mL | 11.4869 mL | |
10 mM | 0.2297 mL | 1.1487 mL | 2.2974 mL | 5.7434 mL | |
20 mM | 0.1149 mL | 0.5743 mL | 1.1487 mL | 2.8717 mL | |
50 mM | 0.0459 mL | 0.2297 mL | 0.4595 mL | 1.1487 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Etravirine 269055-15-4 Microbiology/Virology Proteases/Proteasome HIV Protease Reverse Transcriptase TMC125 TMC 125 R 165335 Inhibitor 依曲韦林 R165335 HIV Human immunodeficiency virus TMC-125 inhibit R-165335 inhibitor