keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Ethynyl estradio 是一种高效的生物活性雌激素。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
25 mg | ¥ 180 | 现货 | ||
50 mg | ¥ 265 | 现货 | ||
100 mg | ¥ 345 | 现货 | ||
200 mg | ¥ 471 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 415 | 现货 |
产品描述 | Ethynyl estradiol is a semisynthetic alkylated ESTRADIOL with a 17-alpha-ethinyl substitution. It has high estrogenic potency when administered orally, and is often used as the estrogenic component in ORAL CONTRACEPTIVES. |
体外活性 | Ethinyl Estradiol increases respiratory chain activity in both cultured rat hepatocytesand HepG2 cells. Ethinyl estradiol is a strong promoter of hepatocarcinogenesis. [1] Ethinyl Estradiol enhances the transcript levels of nuclear genome- and mitochondrial genome-encoded genes and respiratory chain activity in female rat liver, and also inhibits transforming growth factor beta (TGFbeta)-induced apoptosis in cultured liver slices and hepatocytes from female rats. Ethinyl Estradiol increases the transcript levels of the mitochondrial genome-encoded genes cytochrome oxidase subunits I, II, and III in cultured female rathepatocytes. Ethinyl Estradiol significantly increases both the levels of glutathione (reduced [GSH] and oxidized [GSSG] forms) per mg protein in mitochondria and nuclei, while the percentage of total glutathione in the oxidized form is not affected. [2] |
体内活性 | Ethinyl Estradiol (50 mg/kg/day) increases anogenital distance and reduces pup body weight at postnatal day 2, accelerates the age at vaginal opening, reduces F1 fertility and F2 litter sizes, and induces malformations of the external genitalia (5 mg/kg) in the female Long-Evans rat. [3] Ethinyl Estradiol increases the number of low density lipoprotein (LDL) receptors in livers of rats, thereby producing a profound fall in plasma cholesterol levels. Ethinyl Estradiol exerts the same effect in livers of male and female rabbits and that the increase in receptor number is correlated with a 6- to 8-fold increase in the levels of receptor mRNA. [4] |
别名 | 乙炔基雌二醇, 17α-Ethynylestradiol, Ethinyl Estradiol, 炔雌醇 |
分子量 | 296.4 |
分子式 | C20H24O2 |
CAS No. | 57-63-6 |
keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 55 mg/mL (185.6 mM)
Ethanol: 55 mg/mL (185.6 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO / Ethanol | 1 mM | 3.3738 mL | 16.8691 mL | 33.7382 mL | 84.3455 mL |
5 mM | 0.6748 mL | 3.3738 mL | 6.7476 mL | 16.8691 mL | |
10 mM | 0.3374 mL | 1.6869 mL | 3.3738 mL | 8.4345 mL | |
20 mM | 0.1687 mL | 0.8435 mL | 1.6869 mL | 4.2173 mL | |
50 mM | 0.0675 mL | 0.3374 mL | 0.6748 mL | 1.6869 mL | |
100 mM | 0.0337 mL | 0.1687 mL | 0.3374 mL | 0.8435 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Ethynyl estradiol 57-63-6 Endocrinology/Hormones Metabolism Estrogen Receptor/ERR Estrogen/progestogen Receptor Endogenous Metabolite Inhibitor 乙炔基雌二醇 Ethynylestradiol inhibit 17alpha-Ethynylestradiol 17a-Ethynylestradiol 17α-Ethynylestradiol Ethinyl Estradiol 炔雌醇 inhibitor