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Escin

产品编号 T0278 CAS 6805-41-0

别名: Aescin

Escin is biosynthesized from protoaescigenin and barringtogenol, occurring in the seeds of Aesculus.

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Escin , CAS 6805-41-0

规格	库存	价格/RMB	数量
10 mg	上海现货	480.00
1 mL * 10 mM (in DMSO)	上海现货	500.00

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选择批次

纯度 98.00%

HNMR COA

纯度 95.00%

COA

Datasheet SDS

生物活性

化学信息

存储 & 溶解度

产品描述	Escin is biosynthesized from protoaescigenin and barringtogenol, occurring in the seeds of Aesculus.
靶点活性	Others
体外活性	Escin is effective to inhibit pancreatic cancer cell proliferation as a single agent. However, escin has minimal effect on normal rat skeletal muscle cells. Escin potentiates the proliferation-inhibiting and apoptosis-inducing effect of gemcitabine in both BxPC-3 and PANC-1 cell lines in vitro. It also down-regulates constitutive as well as gemcitabine-induced activation of NF-kB and its downstream gene products in pancreatic cancer cells in vitro[1].
体内活性	Escin augments therapeutic effect of gemcitabine in BxPC-3 xenografts in nude mice. They have significant synergistic effects on suppressing the growth of pancreatic tumors, inhibiting the proliferation and inducing apoptosis of tumors. Escin potentiates the inhibiting effect of gemcitabine on NF-kB and NF-kB-regulated gene products in BxPC-3 xenografts in nude mice[1].
细胞实验	Cell cycle analysis: After treatment with escin (BxPC-3 (25 μM),PANC-1 (20 μM),respectively), gemcitabine (BxPC-3(100 nM), PANC-1(1 μM), respectively) or their combinations for 72 h, BxPC-3 and PANC-1 cells are collected by trypsinization, washed with ice-cold PBS and fixed overnight by the addition of 2 ml of ice-cold 70% ethanol/30% PBS at 4°C. The ethanol is subsequently removed after centrifugation, and about 1×106 cells are resuspended in 800 μl of PBS, 100 μl of ribonuclease A (500 g/ml PBS) and 100 μl of PI (500 g/ml PBS) in the dark at room temperature for 30 min. Flow cytometric analysis is performed using FACScan for the detection of the percentage of cells in the diVerent phases of the cell cycle. Cells treated with DMSO alone are used as controls. (Only for Reference) Cell lines: The human pancreatic cancer cell lines BxPC-3, PANC-1

别名	Aescin
纯度	98.00%
分子量	1131.28
分子式	C55H86O24
CAS No.	6805-41-0

存储

Powder: -20°C for 3 years

In solvent: -80°C for 6 months

溶解度

DMSO: 61 mg/mL (53.9 mM)

Ethanol: <1 mg/mL

Water: <1 mg/mL

( < 1 mg/ml refers to the product slightly soluble or insoluble )

文献引用

参考文献

1. Wang YW, et al. J Cancer Res Clin Oncol. 2012, 138(5):785-97.

剂量换算

对于不同动物的给药剂量换算，您也可以参考更多

体内实验配液计算器

第一步：请输入动物实验的基本信息

剂量

mg/kg

每只动物体重

给药体积

动物数量

第二步：请输入动物体内配方组成，不同的产品配方组成不同，如有配方需求，可先联系我们提供正确的体内配方。

% DMSO+

% +

% Tween 80+

% ddH₂O

%DMSO+

计算重置

计算结果如下:

工作液浓度: mg/ml;

母液配置方法: mg 药物溶于 μL DMSO (母液浓度为 mg/mL)，如您需要配置的浓度超过该产品的溶解度，请先与我们联系。

体内配方的制备方法：取 μL DMSO 主液，加入 μL PEG300，混匀澄清，再加 μL Tween 80，混匀澄清，再加 μL ddH₂O, 混匀澄清。

备注:

要按顺序从左向右依次添加助溶剂。可配合物理方法，如涡流、超声波或热水浴使之帮助溶解。

计算器

摩尔浓度计算器

稀释计算器

配液计算器

分子量计算器

质量

浓度

容积

分子量

浓度 (起始)

容积 (起始)

浓度 (终)

容积 (终)

溶液体积

质量

配液浓度

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技术支持

Answers to questions you may have can be found in the Inhibitor Handling Instructions. Topics include how to prepare stock solutions, how to store Products, and issues that need special attention for cell-based assays and animal experiments.

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