store at low temperature,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Emtricitabine (FTC) 是一种核苷逆转录酶抑制剂, 在 PBMC 细胞中的 EC50值为0.01 µM,可研究 HIV 感染。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
25 mg | ¥ 298 | 现货 | ||
50 mg | ¥ 417 | 现货 | ||
100 mg | ¥ 671 | 现货 | ||
500 mg | ¥ 1,136 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 387 | 现货 |
产品描述 | Emtricitabine (FTC) (FTC), a nucleoside reverse transcriptase inhibitor, exhibits inhibition activity against human immunodeficiency virus (HIV) and hepatitis B virus. |
靶点活性 | NRTI:0.01 µM(EC50) |
体内活性 | Reproductive and developmental toxicology studies are performed with emtricitabine. Oral doses up to 1000 mg/kg/day provided a daily area under the curve (AUC0→24) exposure to pregnant animals approximately 60- (mice) to 120-fold (rabbits) higher than that in humans at the recommended dose of 200 mg given once per day. In a mouse fertility study, emtricitabine had no effect on fertility, sperm count, or early embryonic development. There is no increased incidence of malformations in mouse and rabbit embryofetal toxicology studies. The development and fertility of F1 progeny are unaffected by emtricitabine in a mouse pre- and post-natal study. These data shows a favorable pre-clinical reproductive safety profile for emtricitabine[6]. |
细胞实验 | EA.hy926 cells were plated in a 12-, 24- or 96-well plates and grown in DMEM media supplemented with 3% FCS. Endothelial cells from PARP+/+and PARP-/- mice were isolated and cultured. Cell viability was determined by the reduction of yellow MTT into a purple formazan product by mitochondrial dehydrogenases of metabolically active cells. Following the treatment period, the experimental medium was removed and 100 μL MTT (1 mg/mL) added. After 1 h incubation, the MTT solution was carefully removed and the purple crystals were solubilized in 100 μL of DMSO. The DMSO was transferred to an ELISA plate and absorbance measured at 550 nm with a 620 nm[3]. |
别名 | 恩曲他滨, FTC, Emtriva, BW1592 |
分子量 | 247.25 |
分子式 | C8H10FN3O3S |
CAS No. | 143491-57-0 |
store at low temperature,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 50 mg/mL (202.22 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 4.0445 mL | 20.2224 mL | 40.4449 mL | 101.1122 mL |
5 mM | 0.8089 mL | 4.0445 mL | 8.089 mL | 20.2224 mL | |
10 mM | 0.4044 mL | 2.0222 mL | 4.0445 mL | 10.1112 mL | |
20 mM | 0.2022 mL | 1.0111 mL | 2.0222 mL | 5.0556 mL | |
50 mM | 0.0809 mL | 0.4044 mL | 0.8089 mL | 2.0222 mL | |
100 mM | 0.0404 mL | 0.2022 mL | 0.4044 mL | 1.0111 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Emtricitabine 143491-57-0 Microbiology/Virology Proteases/Proteasome HIV Protease Reverse Transcriptase 恩曲他滨 FTC Inhibitor Emtriva BW1592 HIV inhibit BW 1592 BW-1592 Human immunodeficiency virus inhibitor