首页 GPCR/G Protein Histamine Receptor Emedastine
Emedastine
编号 T3979     别名: LY188695, Emadine
CAS 87233-61-2     分子式 C17H26N4O     分子量 302.42
靶点: H1 receptor;
Emedastine is a second generation, selective histamine H1 receptor antagonist with anti-allergic activity. Emedastine reversibly and competitively blocks histamine by binding to H1 receptors, thus blocking its downstream activity. As a result this agent interferes with mediator release from mast cells either by inhibiting calcium ion influx across mast cell/basophil plasma membrane or by inhibiting intracellular calcium ion release within the cells. In addition, emedastine may also inhibit the late-phase allergic reaction mediated through leukotrienes or prostaglandins, or by producing an anti-platelet activating factor effect. Upon ocular administration, emedastine causes a dose-dependent inhibition of histamine-stimulated vascular permeability in the conjunctiva. Emedastine does not affect adrenergic, dopamine, or serotonin receptors.
选择批次  
规格 库存 单价 数量
2 mg 上海现货 1769.00
5 mg 上海现货 3185.00
10 mg 上海现货 4985.00
25 mg 上海现货 8633.00
50 mg 上海现货 14885.00
100 mg 上海现货 20285.00
1 mL * 10 mM (in DMSO) 上海现货 3500.00
大包装特惠,请咨询
大包装特惠,请咨询

生物活性

产品描述

Emedastine is a second generation, selective histamine H1 receptor antagonist with anti-allergic activity. Emedastine reversibly and competitively blocks histamine by binding to H1 receptors, thus blocking its downstream activity. As a result this agent interferes with mediator release from mast cells either by inhibiting calcium ion influx across mast cell/basophil plasma membrane or by inhibiting intracellular calcium ion release within the cells. In addition, emedastine may also inhibit the late-phase allergic reaction mediated through leukotrienes or prostaglandins, or by producing an anti-platelet activating factor effect. Upon ocular administration, emedastine causes a dose-dependent inhibition of histamine-stimulated vascular permeability in the conjunctiva. Emedastine does not affect adrenergic, dopamine, or serotonin receptors.

靶点活性

H1 receptor,

体外活性

体内活性

化学信息

分子量

302.42

分子式

C17H26N4O

CAS

87233-61-2

溶解度

DMSO: 10 mM

( < 1 mg/ml refers to the product slightly soluble or insoluble )

储存条件

store at -80°C

备注

For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.

配制溶液

1 mg 5 mg 10 mg
1 mM 3.307 ml 16.533 ml 33.067 ml
5 mM 0.661 ml 3.307 ml 6.613 ml
10 mM 0.331 ml 1.653 ml 3.307 ml
50 mM 0.066 ml 0.331 ml 0.661 ml
技术支持
在订购、运输、储存和使用我们的产品的任何阶段,您遇到的任何问题,均可以通过拨打我们的热线电话400-998-7375,或者邮箱 info@tsbiochem.com,直接联系到我们。我们会在24小时内尽快联系您。
订购方式
联系陶素
电话:400-821-2233
传真:021-34692979
邮箱:info@tsbiochem.com


  • 关注公众号
    - 超值特惠
    - 客户福利
    - 业界动态
    - 实用攻略
陶素的所有产品和服务仅用于科学研究,我们不为任何其他用途提供产品和服务(也不为任何个人提供产品和服务)。