store at low temperature,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Elexacaftor (VX-445) 是一种囊性纤维化跨膜电导调节因子 (CFTR) 校正剂。它促进CFTR 的加工和转运,增加细胞表面CFTR 的数量。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 828 | 现货 | ||
2 mg | ¥ 1,290 | 现货 | ||
5 mg | ¥ 2,430 | 现货 | ||
10 mg | ¥ 3,750 | 现货 | ||
25 mg | ¥ 6,590 | 现货 | ||
50 mg | ¥ 8,890 | 现货 | ||
100 mg | ¥ 11,800 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 2,680 | 现货 |
产品描述 | Elexacaftor (VX-445) is a modulator of cystic fibrosis transmembrane conductance regulator (CFTR) and it also facilitates the processing and trafficking of CFTR to increase the amount of CFTR at the cell surface. |
体外活性 | Elexacaftor (VX-445) has the potential to treat cystic fibrosis and it also is a next-generation cystic fibrosis transmembrane conductance regulator (CFTR) corrector designed to restore Phe508del CFTR protein function. VX-445-Tezacaftor-VX-770 significantly improves Phe508del CFTR protein processing, trafficking, chloride transport. To a greater extent than any two of these agents in dual combination[2]. |
别名 | VX-445 |
分子量 | 597.65 |
分子式 | C26H34F3N7O4S |
CAS No. | 2216712-66-0 |
store at low temperature,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 125 mg/mL (209.15 mM), Sonification is recommended.
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 1.6732 mL | 8.3661 mL | 16.7322 mL | 41.8305 mL |
5 mM | 0.3346 mL | 1.6732 mL | 3.3464 mL | 8.3661 mL | |
10 mM | 0.1673 mL | 0.8366 mL | 1.6732 mL | 4.1831 mL | |
20 mM | 0.0837 mL | 0.4183 mL | 0.8366 mL | 2.0915 mL | |
50 mM | 0.0335 mL | 0.1673 mL | 0.3346 mL | 0.8366 mL | |
100 mM | 0.0167 mL | 0.0837 mL | 0.1673 mL | 0.4183 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Elexacaftor 2216712-66-0 Autophagy Membrane transporter/Ion channel CFTR Fibrosis Cystic fibrosis transmembrane conductance regulator Inhibitor Cystic VX 445 inhibit VX445 VX-445 inhibitor