Eflornithine hydrochloride hydrate

产品编号: T2593 别名:

依氟鸟氨酸盐酸盐一水合物,Difluoromethylornithine hydrochloride hydrate,RMI-71782 hydrochloride hydrate,DFMO hydrochloride hydrate,Eflornithine hydrochloride Monohydrate,Eflornithine hydrochloride,α-difluoromethylornithine hydrochloride hydrate,MDL-71782 hydrochloride hydrate

Eflornithine hydrochloride Monohydrate 是一种特异性的、不可逆的酶鸟氨酸脱羧酶抑制剂。它可用于研究非洲锥虫病和女性面部毛发过度生长。

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CAS：96020-91-6

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生物活性化学信息储存和溶解度信息参考文献引用文献

产品描述

Eflornithine hydrochloride is a specific, irreversible inhibitor of ornithine decarboxylase.

体外活性

When cultured cells are treated with α-difluoromethyl-Orn, an inhibitor of polyamine biosynthesis, production of hydrogen peroxide is suppressed and programmed cell death did not occur[1].

体内活性

Eflornithine is the only new molecule registered for the treatment of human African trypanosomiasis over the last 50 years. It is the drug used mainly as a back-up for melarsoprol refractory Trypanosoma brucei gambiense cases[2]. Eflornithine 15% cream is superior to a placebo in reducing hair growth in subjects with excessive, unwanted facial hair. After 24 weeks' treatment, 58% of eflornithine and 34% of placebo subjects have at least some improvement in facial hirsutism[3]. The hair growth inhibitory activity of eflornithine is significantly enhanced when the eflornithine cream is applied onto a mouse skin area pretreated with microneedles[4]. Treatment of coarctation hypertensive rats with eflornithine results in a normalization of the contractile intensity to KCI and norepinephrine and relaxations to acetylcholine by 14 days of hypertension[5].

细胞实验

BY2 cells are treated with or without cryptogein in the presence or absence of DFMO(Difluoromethylornithine) and monitered the effect of chemicals on cell growth. (Only for Reference)

Cas No.

96020-91-6

分子式

C6H15ClF2N2O3

分子量

236.64

别名

依氟鸟氨酸盐酸盐一水合物;Difluoromethylornithine hydrochloride hydrate;RMI-71782 hydrochloride hydrate;DFMO hydrochloride hydrate;Eflornithine hydrochloride Monohydrate;Eflornithine hydrochloride;α-difluoromethylornithine hydrochloride hydrate;MDL-71782 hydrochloride hydrate;Eflornithine hydrochloride hydrate

参考文献

[1]Yoda H, et al. Plant Physiol. 2006, 142(1):193-206.[2]Mastrodomenico V, Esin J J, Graham M L, et al. Polyamine depletion inhibits bunyavirus infection via generation of noninfectious interfering virions[J]. Journal of virology. 2019 May 1. pii: JVI.00530-19.[3]Balfour JA, et al. Topical eflornithine. Am J Clin Dermatol. 2001;2(3):197-201; discussion 202.[4]Dial C N, Tate P M, Kicmal T M, et al. Coxsackievirus B3 Responds to Polyamine Depletion via Enhancement of 2A and 3C Protease Activity[J]. Viruses. 2019 Apr 30;11(5).[5]Kumar A, et al. A method to improve the efficacy of topical eflornithine hydrochloride cream. Drug Deliv. 2016 Jun;23(5):1495-501.[6]Lipke DW, et al. Eflornithine alters changes in vascular responsiveness associated with coarctation hypertension. Clin Exp Hypertens. 1997 Apr;19(3):297-312.[7]Dial C N. Modulation of Coxsackievirus Protease Activity by Polyamines[D]. Loyola University Chicago. 2019.[8]Kicmal T M, Tate P M, Dial C N, et al. Polyamine depletion abrogates enterovirus cellular attachment[J]. Journal of virology. 2019, 93(20): e01054-19.[9]Burri C, et al. Eflornithine for the treatment of human African trypanosomiasis. Parasitol Res. 2003 Jun;90 Supp 1:S49-52.

引用文献

[1]Mastrodomenico V, Esin J J, Graham M L, et al. Polyamine depletion inhibits bunyavirus infection via generation of noninfectious interfering virions. Journal of Virology. 2019 May 1. pii: JVI.00530-19 [2]Kicmal T M, Tate P M, Dial C N, et al. Polyamine depletion abrogates enterovirus cellular attachment. Journal of Virology. 2019, 93(20): e01054-19 [3]Dial C N, Tate P M, Kicmal T M, et al. Coxsackievirus B3 Responds to Polyamine Depletion via Enhancement of 2A and 3C Protease Activity. Viruses. 2019 Apr 30;11(5)

储存和溶解度

DMSO:2.5 mM
Powder: -20°C for 3 years
In solvent: -80°C for 2 years

剂量换算 Eflornithine hydrochloride hydrate 96020-91-6

对于各种应用，安全且有效的用药剂量是很有必要的了解更多

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第二步：请输入动物体内配方组成，不同的产品配方组成不同，如有配方需求，可先联系我们提供正确的体内配方。

% DMSO +

% +

% Tween 80 +

% ddH₂O

% DMSO +

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计算结果如下:

工作液浓度: mg/ml;

母液配置方法: mg 药物溶于 μL DMSO (母液浓度为 mg/mL)，如您需要配置的浓度超过该产品的溶解度，请先与我们联系。

体内配方的制备方法：取 μL DMSO 主液，加入 μL PEG300，混匀澄清，再加 μL Tween 80，混匀澄清，再加 μL ddH₂O, 混匀澄清。

备注:

要按顺序从左向右依次添加助溶剂。可配合物理方法，如涡流、超声波或热水浴使之帮助溶解。

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技术支持

在抑制剂处理说明中可以找到您可能遇到的问题的答案。主题包括如何准备储备溶液，如何存储产品以及基于细胞的测定和动物实验需要特别注意的问题。

Keywords

inhibit DFMO hydrochloride α-difluoromethylornithine hydrochloride 依氟鸟氨酸盐酸盐一水合物 Eflornithine hydrochloride hydrate Difluoromethylornithine hydrochloride hydrate RMI-71782 hydrochloride hydrate DFMO hydrochloride hydrate Inhibitor Eflornithine hydrochloride Monohydrate Eflornithine hydrochloride MDL-71782 hydrochloride α-difluoromethylornithine hydrochloride hydrate MDL-71782 hydrochloride hydrate RMI-71782 hydrochloride Parasite

注册成功

Eflornithine hydrochloride hydrate

依氟鸟氨酸盐酸盐一水合物,Difluoromethylornithine hydrochloride hydrate,RMI-71782 hydrochloride hydrate,DFMO hydrochloride hydrate,Eflornithine hydrochloride Monohydrate,Eflornithine hydrochloride,α-difluoromethylornithine hydrochloride hydrate,MDL-71782 hydrochloride hydrate

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