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Dynasore

产品编号 T1848 CAS 304448-55-3

别名: Dynamin Inhibitor I

Dynasore (Dynamin Inhibitor I) 是一种可渗透细胞的化学物质，可逆且非竞争性地抑制 dynamin 1/2 的 GTPase 活性。它还抑制线粒体动力蛋白 Drp1，对其他小 GTPase 没有影响。

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Dynasore, CAS 304448-55-3

规格	价格/CNY	货期
1 mg	￥ 163	现货
5 mg	￥ 359	现货
10 mg	￥ 578	现货
25 mg	￥ 1,070	现货
50 mg	￥ 1,860	现货
100 mg	￥ 2,630	现货
200 mg	￥ 3,960	现货
500 mg	￥ 6,360	现货
1 mL * 10 mM (in DMSO)	￥ 638	现货

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选择批次

纯度: 99.89%

纯度: 99.22%

纯度: 95.85%

更多批次查询请联系客服

生物活性

化学信息

存储 & 溶解度

参考文献

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度

Ethanol: 1.6 mg/mL (5 mM)

DMSO: 32.2 mg/mL (100 mM)

溶液配制表

可选溶剂	浓度体积质量	1 mg	5 mg	10 mg	25 mg
Ethanol / DMSO	1 mM	3.1026 mL	15.513 mL	31.026 mL	77.5651 mL
Ethanol / DMSO	5 mM	0.6205 mL	3.1026 mL	6.2052 mL	15.513 mL
DMSO	10 mM	0.3103 mL	1.5513 mL	3.1026 mL	7.7565 mL
	20 mM	0.1551 mL	0.7757 mL	1.5513 mL	3.8783 mL
	50 mM	0.0621 mL	0.3103 mL	0.6205 mL	1.5513 mL
	100 mM	0.031 mL	0.1551 mL	0.3103 mL	0.7757 mL

计算器

摩尔浓度计算器

稀释计算器

配液计算器

分子量计算器

质量

浓度

容积

分子量

浓度 (起始)

容积 (起始)

浓度 (终)

容积 (终)

溶液体积

质量

配液浓度

参考文献

1. Macia E, et al. Dev Cell, 2006, 10(6), 839-850. 2. Newton AJ, et al. Proc Natl Acad Sci USA, 2006, 103(47), 17955-17960. 3. Abban CY, et al. Am J Ther, 2008, 15(4), 304-311. 4. Li G, et al. Dynasore Improves Motor Function Recovery via Inhibition of Neuronal Apoptosis and Astrocytic Proliferation after Spinal Cord Injury in Rats. Mol Neurobiol. 2016 Nov 7. 5. Xu L L, Zhang X, Jiang Z Y, et al. Molecular similarity guided optimization of novel Nrf2 activators with 1, 2, 4-oxadiazole core[J]. Bioorganic & medicinal chemistry. 2016, 24(16): 3540-3547. 6. Wang X, Chen Q Z, Zan Y X, et al. . Exosomal miR‐145‐5p derived from orthohantavirus‐infected endothelial cells inhibits HTNV infection. The FASEB Journal. 2020, 34(10): 13809-13825. 7. Zhong B, Shi D, Wu F, et al. Dynasore suppresses cell proliferation, migration, and invasion and enhances the antitumor capacity of cisplatin via STAT3 pathway in osteosarcoma[J]. Cell death & disease. 2019, 10(10): 1-16. 8. Jiang K, Hou X, Tan T, et al. Scavenger receptor-C acts as a receptor for Bacillus thuringiensis vegetative insecticidal protein Vip3Aa and mediates the internalization of Vip3Aa via endocytosis[J]. PLoS pathogens. 2018 Oct 4;14(10):e1007347. 9. Zhang Y, Xue W, Zhang W, et al. Histone methyltransferase G9a protects against acute liver injury through GSTP1. Cell Death & Differentiation. 2019: 1-16.

文献引用

1. Zhao Z, Wei Z, Zheng J, et al.Hepatitis B virus promotes its own replication by enhancing RAB5A-mediated dual activation of endosomal and autophagic vesicle pathways: RAB5A promotes HBV replication.Emerging Microbes & Infections.2023 (just-accepted): 2261556. 2. Zhu X, Zhao Y, Liu Y, et al.Macrophages release IL11-containing filopodial tip vesicles and contribute to renal interstitial inflammation.Cell Communication and Signaling.2023, 21(1): 1-17. 3. Wang T, Wang L, Li W, et al.Fowl adenovirus serotype 4 enters leghorn male hepatocellular cells via the clathrin-mediated endocytosis pathway.Veterinary Research.2023, 54(1): 1-14. 4. Xu L L, Zhang X, Jiang Z Y, et al. Molecular similarity guided optimization of novel Nrf2 activators with 1, 2, 4-oxadiazole core. Bioorganic & medicinal chemistry. 2016, 24(16): 3540-3547. 5. Jiang K, Hou X, Tan T, et al. Scavenger receptor-C acts as a receptor for Bacillus thuringiensis vegetative insecticidal protein Vip3Aa and mediates the internalization of Vip3Aa via endocytosis. PLoS Pathogens. 2018 Oct 4;14(10):e1007347 6. Zhang Y, Xue W, Zhang W, et al. Histone methyltransferase G9a protects against acute liver injury through GSTP1. Cell Death & Differentiation. 2020, 27(4): 1243-1258 7. Zhong B, Shi D, Wu F, et al. Dynasore suppresses cell proliferation, migration, and invasion and enhances the antitumor capacity of cisplatin via STAT3 pathway in osteosarcoma. Cell Death & Disease. 2019, 10(10): 1-16 8. Lu J Y, Huang W T, Zhou K, et al. Microbial Lipopeptide Supramolecular Self‐Assemblies as a Methuosis‐Like Cell Death Inducer with In Vivo Antitumor Activity. Small. 2021: 2104034. 9. Wang X, Chen Q Z, Zan Y X, et al. Exosomal miR‐145‐5p derived from orthohantavirus‐infected endothelial cells inhibits HTNV infection. The FASEB Journal. 2020, 34(10): 13809-13825. 10. Xia T, Liu Z, Du Y, et al.Bifunctional iRGD-Exo-DOX crosses the blood-brain barrier to target central nervous system lymphoma.Biochemical Pharmacology.2024: 116138.

剂量换算

对于不同动物的给药剂量换算，您也可以参考 更多...

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL，一共给药动物10 只，您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。

母液配置方法：2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL)，如您需要配置的浓度超过该产品的溶解度，请先与我们联系。

体内配方的制备方法：取 50 μL DMSO 主液，加入 300 μL PEG300，混匀澄清，再加 50 μL Tween 80，混匀澄清，再加 600 μL ddH2O, 混匀澄清。

第一步：请输入动物实验的基本信息

剂量

mg/kg

每只动物体重

给药体积

μL

动物数量

第二步：请输入动物体内配方组成，不同的产品配方组成不同，如有配方需求，可先联系我们提供正确的体内配方。

% DMSO+

% +

% Tween 80+

% ddH₂O

%DMSO+

计算重置

计算结果如下:

工作液浓度: mg/ml;

母液配置方法: mg 药物溶于 μL DMSO (母液浓度为 mg/mL)，如您需要配置的浓度超过该产品的溶解度，请先与我们联系。

体内配方的制备方法：取 μL DMSO 主液，加入 μL PEG300，混匀澄清，再加 μL Tween 80，混匀澄清，再加 μL ddH₂O, 混匀澄清。

备注:

要按顺序从左向右依次添加助溶剂。可配合物理方法，如涡流、超声波或热水浴使之帮助溶解。

技术支持

您可能有的问题的答案可以在抑制剂处理说明中找到，包括如何准备库存溶液，如何存储产品，以及基于细胞的分析和动物实验需要特别注意的问题。

Keywords

Dynasore 304448-55-3 Autophagy Cytoskeletal Signaling Microbiology/Virology Virus Protease Dynamin HSV Inhibitor Herpes simplex virus inhibit Dynamin Inhibitor I inhibitor

我们的所有产品和服务仅用于科学研究，不能被用于人体，我们也不向个人提供产品和服务。

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产品描述	Dynasore (Dynamin Inhibitor I), a cell-permeable chemical, can reversibly and non-competitivity inhibit GTPase activity of dynamin 1/2 (IC50: 15 μM in a cell-free assay). It also inhibits the mitochondrial dynamin Drp1, with no effect against other small GTPase.
靶点活性	Dynamin1/2:15 μM
体内活性	Dynasore ameliorates the motor dysfunction greatly at 3, 7, and 10 days after SCI in rats. Dynasore markedly enhances motor function which may be through inhibiting the activation of neuronal mitochondrial apoptotic pathway and astrocytic proliferation in rats after SCI[4].
激酶实验	RIP1 kinase assay: Phosphorylation of RIP1 requires its kinase activity. Expression constructs of FLAGtagged wild-type (WT) or a kinase-inactive point mutant of RIP1 (K45M) are are transfected into 293T cells and RIP1 kinase assay is performed as described in the Methods in the presence of [γ-32P]ATP for 30 min at 30℃. Samples are subjected to SDS-PAGE and RIP1 band is visualized by autoradiography. Relative intensities of radioactive bands are quantified and are shown (ratio) in this and all other autoradiographs. In parallel to kinase reactions, a sample of beads is subjected to western blot analysis using anti-RIP1 antibody to ensure equal protein amounts in kinase reactions.
细胞实验	Mouse ventricular myocytes are isolated from male adult C6/Black mouse. Cardiomyocytes subjects to 2 hours of drug treatment followed by oxidative stress (30 μM Water2 for 35 min). For ATP supplement experiments, the cells are treated with 3 mM ATP for 30 min before exposure to Water2. Cardiomyocyte survival and viability are analyzed by trypan blue exclusion (TBE) assay[3].

Dynasore

存储

溶解度

溶液配制表

计算器

输入分子式，点击计算，可计算出产品的分子量。

参考文献

文献引用

相关产品

相关化合物库

剂量换算

体内实验配液计算器

技术支持

Keywords

别名	Dynamin Inhibitor I
分子量	322.31
分子式	C18H14N2O4
CAS No.	304448-55-3