首页 GPCR/G Protein Histamine Receptor Doxylamine succinate
Doxylamine succinate
编号 T1115     别名: Decapryn
CAS 562-10-7     分子式 C21H28N2O5     分子量 388.46
靶点: H1 receptor;
Doxylamine Succinate is a pyridine derivate histamine H1 antagonist with pronounced sedative properties. Doxylamine succinate competitively blocks the histamine H1 receptor and limits the typical allergic and anaphylactic responses, including bronchoconstriction, vasodilation, increased capillary permeability, and spasmodic contraction of the gastrointestinal smooth muscle, caused by actions of histamine on bronchial and gastrointestinal smooth muscles, and on capillaries. This drug also prevents histamine-induced pain and itching of the skin and mucous membranes.
选择批次  
规格 库存 单价 数量
50 mg 上海现货 410.00
100 mg 上海现货 557.00
200 mg 上海现货 934.00
1 mL * 10 mM (in DMSO) 上海现货 410.00
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生物活性

产品描述

Doxylamine Succinate is a pyridine derivate histamine H1 antagonist with pronounced sedative properties. Doxylamine succinate competitively blocks the histamine H1 receptor and limits the typical allergic and anaphylactic responses, including bronchoconstriction, vasodilation, increased capillary permeability, and spasmodic contraction of the gastrointestinal smooth muscle, caused by actions of histamine on bronchial and gastrointestinal smooth muscles, and on capillaries. This drug also prevents histamine-induced pain and itching of the skin and mucous membranes.

靶点活性

H1 receptor,

体外活性

体内活性

在B6C3F1小鼠体内,以Doxylamine琥珀酸盐形式,食物摄取7天或15天(饮食中含量0, 40, 375, 750, or 1500 ppm, 以游离碱Doxylamine形式)的方式考察了Doxylamine对微粒体酶活性和血清甲状腺激素水平的影响.结果发现在B6C3F1小鼠体内,Doxylamine是肝微粒体细胞色素P450Â的巴比妥类诱导剂,且与Doxylamine提升了参与T4代谢的肝酶活性的假说相一致.

化学信息

分子量

388.46

分子式

C21H28N2O5

CAS

562-10-7

溶解度

DMSO: 100 mg/mL (257.43 mM)

Water: 100 mg/mL (257.43 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

储存条件

store at -80°C

备注

For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.

配制溶液

1 mg 5 mg 10 mg
1 mM 2.574 ml 12.871 ml 25.743 ml
5 mM 0.515 ml 2.574 ml 5.149 ml
10 mM 0.257 ml 1.287 ml 2.574 ml
50 mM 0.051 ml 0.257 ml 0.515 ml
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