首页 GPCR/G Protein Histamine Receptor Diphenhydramine hydrochloride
Diphenhydramine hydrochloride
编号 T0330     别名: DPH, Diphenhydramine HCl
CAS 147-24-0     分子式 C17H22ClNO     分子量 291.82
靶点: H1 receptor;
Diphenhydramine HCl (Benadryl) is a histamine H1 antagonist used as an antitussive and antiemetic. It is also used for pruritus and dermatoses, for hypersensitivity reactions, as an antiparkinson, a hypnotic, and as an ingredient in common cold preparations.
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规格 库存 单价 数量
200 mg 上海现货 350.00
500 mg 上海现货 618.00
1 mL * 10 mM (in DMSO) 上海现货 148.00
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生物活性

产品描述

Diphenhydramine HCl (Benadryl) is a histamine H1 antagonist used as an antitussive and antiemetic. It is also used for pruritus and dermatoses, for hypersensitivity reactions, as an antiparkinson, a hypnotic, and as an ingredient in common cold preparations.

靶点活性

H1 receptor,

体外活性

Diphenhydramine blocks tetrodotoxin-sensitive (TTX-S) and tetrodotoxin-resistant (TTX-R) sodium currents with K(d) values of 48 mM and 86 mM, respectively, at a holding potential of -80 mV. Diphenhydramine shifts the conductance-voltage curve for TTX-S sodium currents in the depolarizing direction but has little effect on that for TTX-R sodium currents. Diphenhydramine causes a shift of the steady-state inactivation curve for both types of sodium currents in the hyperpolarizing direction. Diphenhydramine produces a profound use-dependent block when the cells are repeatedly stimulated with high-frequency depolarizing pulses. [1] Diphenhydramine induces apoptosis in a dose- and time-dependent manner in both CCRF-CEM and Jurkat cell lines, whereas Cimetidine fails to induce significant effects at similar concentrations. Diphenhydramine-induced apoptosis is evaluated in terms of morphology, flow cytometry, and the release of cytochrome c to the cytosol. Diphenhydramine inhibits cell proliferation without inducing apoptosis in human peripheral blood mononuclear cells. [2] Diphenhydramine (500 nM) significantly reduces the baseline firing of the periaqueductal gray neurons without a significant effect on the frequency of postsynaptic potentials. Diphenhydramine at high concentration inhibits periaqueductal gray neurons, but at low concentrations it has no effect on the baseline-firing rate and it blocks the response to neurotensin and tomedial preoptic nucleus stimulation. [3]

体内活性

化学信息

分子量

291.82

分子式

C17H22ClNO

CAS

147-24-0

溶解度

DMSO: 18 mg/mL (61.68 mM), Need ultrasonic and warming

( < 1 mg/ml refers to the product slightly soluble or insoluble )

储存条件

store at -80°C

备注

For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.

配制溶液

1 mg 5 mg 10 mg
1 mM 3.427 ml 17.134 ml 34.268 ml
5 mM 0.685 ml 3.427 ml 6.854 ml
10 mM 0.343 ml 1.713 ml 3.427 ml
50 mM 0.069 ml 0.343 ml 0.685 ml
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