Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Diphenhydramine hydrochloride (DPH) 是一种组胺 H1 拮抗剂,用作镇咳药和止吐药。它还用于治疗瘙痒和皮肤病、过敏反应、抗帕金森病、催眠药和普通感冒制剂的成分。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
200 mg | ¥ 294 | 现货 | ||
500 mg | ¥ 519 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 157 | 现货 |
产品描述 | Diphenhydramine hydrochloride (DPH) is a histamine H1 antagonist used as an antitussive and antiemetic. It is also used for pruritus and dermatoses, for hypersensitivity reactions, as an antiparkinson, a hypnotic, and as an ingredient in common cold preparations. |
体外活性 | Diphenhydramine blocks tetrodotoxin-sensitive (TTX-S) and tetrodotoxin-resistant (TTX-R) sodium currents with K(d) values of 48 mM and 86 mM, respectively, at a holding potential of -80 mV. Diphenhydramine shifts the conductance-voltage curve for TTX-S sodium currents in the depolarizing direction but has little effect on that for TTX-R sodium currents. Diphenhydramine causes a shift of the steady-state inactivation curve for both types of sodium currents in the hyperpolarizing direction. Diphenhydramine produces a profound use-dependent block when the cells are repeatedly stimulated with high-frequency depolarizing pulses. [1] Diphenhydramine induces apoptosis in a dose- and time-dependent manner in both CCRF-CEM and Jurkat cell lines, whereas Cimetidine fails to induce significant effects at similar concentrations. Diphenhydramine-induced apoptosis is evaluated in terms of morphology, flow cytometry, and the release of cytochrome c to the cytosol. Diphenhydramine inhibits cell proliferation without inducing apoptosis in human peripheral blood mononuclear cells. [2] Diphenhydramine (500 nM) significantly reduces the baseline firing of the periaqueductal gray neurons without a significant effect on the frequency of postsynaptic potentials. Diphenhydramine at high concentration inhibits periaqueductal gray neurons, but at low concentrations it has no effect on the baseline-firing rate and it blocks the response to neurotensin and tomedial preoptic nucleus stimulation. [3] |
别名 | 盐酸苯海拉明, Diphenhydramine HCl, DPH |
分子量 | 291.82 |
分子式 | C17H22ClNO |
CAS No. | 147-24-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 18 mg/mL (61.68 mM), sonification/heating is recommended.
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 3.4268 mL | 17.1338 mL | 34.2677 mL | 85.6692 mL |
5 mM | 0.6854 mL | 3.4268 mL | 6.8535 mL | 17.1338 mL | |
10 mM | 0.3427 mL | 1.7134 mL | 3.4268 mL | 8.5669 mL | |
20 mM | 0.1713 mL | 0.8567 mL | 1.7134 mL | 4.2835 mL | |
50 mM | 0.0685 mL | 0.3427 mL | 0.6854 mL | 1.7134 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Diphenhydramine hydrochloride 147-24-0 GPCR/G Protein Immunology/Inflammation Neuroscience Histamine Receptor Endogenous Metabolite 盐酸苯海拉明 Inhibitor Diphenhydramine HCl Diphenhydramine Hydrochloride Diphenhydramine inhibit DPH inhibitor