Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Dimethyl biphenyl-4,4'-dicarboxylate (Biphenyl dimethyl dicarboxylate) 是一种保肝剂,提取自五味子中,能够诱导 IFN 相关的信号转导。
产品描述 | Dimethyl biphenyl-4,4'-dicarboxylate (Biphenyl dimethyl dicarboxylate) is a planar biphenyldicarboxylic acid ester used as a hepatoprotectant in the treatment of chronic hepatitis. |
体外活性 | Dimethyl biphenyl-4,4'-dicarboxylate(DDB) (200 ug/10(6) cells) efficiently protected the hepatocytes against carbon tetrachloride (10 mM) and D-galactosamine (1 mM) induced damages.?Membrane lipid peroxidation (malondialdehyde, MDA) formation and Glutamic Pyruvic Transaminase (GPT) released from the hepatocytes were markedly decreased.?The damage of the cell surfaces of the hepatocytes were also reduced as seen under a scanning electron microscope (SEM)[1]. |
体内活性 | Pretreatment with DDB (300 mg/kg) orally could ameliorate the reduction of liver glycogen and blood glucose caused by injection of D-gal (800 mg/kg i. p) in mice.?When normal rats received 300 mg/kg of DDB once daily for 10 days, free ribosomal protein and RNA in the liver increased significantly[1]. |
别名 | Biphenyl dimethyl dicarboxylate, 联苯二甲酸二甲酯 |
分子量 | 270.28 |
分子式 | C16H14O4 |
CAS No. | 792-74-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
H2O: 2.5 mM
DMSO: Insoluble
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
H2O | 1 mM | 3.6999 mL | 18.4993 mL | 36.9987 mL | 92.4967 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Dimethyl biphenyl-4,4'-dicarboxylate 792-74-5 Others Dimethyl biphenyl4,4'dicarboxylate Dimethyl biphenyl 4,4' dicarboxylate inhibit Biphenyl dimethyl dicarboxylate Inhibitor 联苯二甲酸二甲酯 inhibitor