Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Dihydrorotenone 是一种线粒体抑制剂,是天然杀虫剂。它通过触发内质网应激并激活 p38 信号通路来诱导人浆细胞凋亡,可能诱发帕金森综合症。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 1,070 | 现货 | ||
5 mg | ¥ 2,830 | 现货 | ||
10 mg | ¥ 4,180 | 现货 | ||
25 mg | ¥ 6,690 | 现货 | ||
50 mg | ¥ 9,120 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 2,970 | 现货 |
产品描述 | Dihydrorotenone is a potent mitochondrial inhibitor and probably induces Parkinsonian syndrome. |
体外活性 | Dihydrorotenone arrested human plasma cancer cells at the G0/G1 phase of the cell cycle. Dihydrorotenone inhibited cyclin D2 transactivation, thus inhibiting its mRNA expression. In addition, Dihydrorotenone upregulated the cell cycle repressors p21 and p53. Dihydrorotenone also increased the phosphorylation level of p53, suggesting the upregulated transactivation function of p53, which was confirmed by the induction of p21, a substrate of activated p53. Moreover, Dihydrorotenone downregulated AKT and ERK phosphorylation, an incentive of cell cycle progression. |
分子量 | 396.43 |
分子式 | C23H24O6 |
CAS No. | 6659-45-6 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 27.5 mg/mL (69.37 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 2.5225 mL | 12.6126 mL | 25.2251 mL | 63.0628 mL |
5 mM | 0.5045 mL | 2.5225 mL | 5.045 mL | 12.6126 mL | |
10 mM | 0.2523 mL | 1.2613 mL | 2.5225 mL | 6.3063 mL | |
20 mM | 0.1261 mL | 0.6306 mL | 1.2613 mL | 3.1531 mL | |
50 mM | 0.0505 mL | 0.2523 mL | 0.5045 mL | 1.2613 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Dihydrorotenone 6659-45-6 Apoptosis Metabolism Mitochondrial Metabolism inhibit Inhibitor inhibitor