首页Chromatin/EpigeneticEpigenetic Reader DomainDiflunisal
Diflunisal
编号 T0808     别名: MK-647, Dolobid, Dolobis, Flovacil, Fluniget
CAS 22494-42-4     分子式 C13H8F2O3     分子量 250.20
靶点: p300;
Diflunisal is a cyclooxygenase (COX) Inhibitor, used as an anti-inflammatory analgesic.
纯度:99.42%
规格 库存 单价 数量
25 mg 上海现货 240.00
50 mg 上海现货 360.00
100 mg 上海现货 640.00
200 mg 上海现货 1152.00
500 mg 上海现货 2157.00
1 mL * 10 mM (in DMSO) 上海现货 160.00
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生物活性

产品描述

Diflunisal is a cyclooxygenase (COX) Inhibitor, used as an anti-inflammatory analgesic.

靶点活性

p300,996μM

体外活性

Diflunisal, an FDA-approved drug containing a salicylic acid substructure, inhibited CBP/p300 more potently than salicylate. Diflunisal exhibits anti-tumor activity against a specific leukemia carrying a t(8;21) translocation, a tumor previously reported to be dependent on p300 in vitro and in vivo[2].

体内活性

Diflunisal-mediated kinetic stabilization of TTR(Rate-limiting transthyretin) should ameliorate TTR amyloidoses, provided that the nonsteroidal anti-inflammatory drug liabilities can be managed clinically[3].

细胞实验

HEK293T cells are transfected with expression vectors for WT p300 or catalitycally inactive mutant. 24 hr after transfection, cells are treated with diflunisal as indicated for 24 hr. H2B acetylation is measured by Western Blot using specified antibodies. Experiments are repeated four times. (Only for Reference)

细胞系: HEK293T cells

动物实验

动物模型:FeSprague-Dawley rats, FeNew Zealand White Rabbits

化学信息

分子量

250.20

分子式

C13H8F2O3

CAS

22494-42-4

溶解度

DMSO: 10 mM

Ethanol: 20 mg/mL (79.94 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

储存条件

store at -80°C

备注

For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.

配制溶液

1 mg 5 mg 10 mg
1 mM 3.997 ml 19.984 ml 39.968 ml
5 mM 0.799 ml 3.997 ml 7.994 ml
10 mM 0.4 ml 1.998 ml 3.997 ml
50 mM 0.08 ml 0.4 ml 0.799 ml
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