首页 Immunology/Inflammation FLAP Diflapolin
Diflapolin
编号 T8844    
CAS 724453-98-9     分子式 C22H17Cl2N3O2S     分子量 458.4
靶点:
Diflapolin is a highly active dual 5-lipoxygenase-activating protein (FLAP)/soluble epoxide hydrolase (sEH) inhibitor with marked anti-inflammatory efficacy and high target selectivity.
选择批次  
规格 库存 单价 数量
1 mg 上海现货 377.00
5 mg 上海现货 626.00
10 mg 上海现货 1116.00
25 mg 上海现货 2349.00
50 mg 上海现货 3915.00
100 mg 上海现货 6264.00
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生物活性

产品描述

Diflapolin is a highly active dual 5-lipoxygenase-activating protein (FLAP)/soluble epoxide hydrolase (sEH) inhibitor with marked anti-inflammatory efficacy and high target selectivity.

靶点活性

体外活性

Diflapolin inhibits 5-LOX product formation in intact human monocytes and neutrophils with IC50s of  30 and 170 nM, respectively, and suppressed the activity of isolated sEH (IC50=20 nM).

体内活性

Diflapolin (1-10 mg/kg; i.p.; 30 min before zymosan injection) exhibits potent anti-inflammatory properties in in-vivo experiments

化学信息

分子量

458.4

分子式

C22H17Cl2N3O2S

CAS

724453-98-9

溶解度

DMSO: 84mg/mL (183.26mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

储存条件

0-4℃ for short term (days to weeks), or -20℃ for long term (months).

备注

For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.

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